114438-33-4
Chemical Structure
N-Hydroxy sulfamethoxazole
Synonym(s): Sulfamethoxazole hydroxylamine
- CAS No.: 114438-33-4
- Formula:C10H11N3O4S
- Molecular Weight:269.28
IUPAC Name: 4-(hydroxyamino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide
InChIKey: MJAMPGKHIZXVFJ-UHFFFAOYSA-N
SMILES: O=S(=O)(NC1=NOC(=C1)C)C2=CC=C(C=C2)NO
Biological Activity: N-Hydroxy sulfamethoxazole (Sulfamethoxazole hydroxylamine) is a Sulfamethoxazole (HY-B0322) metabolite formed by CYP2C9 oxidation that oxidizes hemoglobin to methemoglobin. N-Hydroxy sulfamethoxazole induces haptenation on the surface of viable leukocytes, neutrophil apoptosis, and inhibits neutrophil function. N-Hydroxy sulfamethoxazole is associated with hypersensitivity reactions and can be used in the study of hypersensitivity reactions[1][2].
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N-Hydroxy sulfamethoxazole | N-Hydroxy sulfamethoxazole (Sulfamethoxazole hydroxylamine) is a Sulfamethoxazole (HY-B0322) metabolite formed by CYP2C9 oxidation that oxidizes hemoglobin to methemoglobin. N-Hydroxy sulfamethoxazole induces haptenation on the surface of viable leukocytes, neutrophil apoptosis, and inhibits neutrophil function. N-Hydroxy sulfamethoxazole is associated with hypersensitivity reactions and can be used in the study of hypersensitivity reactions. | |||||||||||||||||||||
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References
- [1]. Naisbitt DJ, et al. Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity. British journal of pharmacology. 1999 Mar;126(6):1393-407.
- [2]. Ott G, et al. Reduction of sulfamethoxazole hydroxylamine (SMX-HA) by the mitochondrial amidoxime reducing component (mARC). Chemical research in toxicology. 2014 Oct 20;27(10):1687-95.
