1154403-54-9
Chemical Structure
GPVGPS
- CAS No.: 1154403-54-9
- Formula:C22H36N6O8
- Molecular Weight:512.56
InChIKey: YABRJLYHDADPFQ-XSWJXKHESA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(NCC(N2[C@@H](CCC2)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)CN
Biological Activity: GPVGPS is a low-molecular-weight fish collagen peptide. GPVGPS upregulates the expression of vascular endothelial growth factor (VEGF), PCNA, hepatocyte growth factor, epidermal growth factor (EGF) , and insulin-like growth factor 1 (IGF-1), and downregulates the expression of negative regulatory proteins associated with hair health. GPVGPS inhibits MMP-1, MMP-2, and MMP-9, increases skin water content, reduces wrinkles, and improves oxidative stress status and pro-inflammatory cytokine levels. GPVGPS can be used in studies related to hair loss and UVB-induced skin photoaging[1][2][3][4].
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GPVGPS | GPVGPS is a low-molecular-weight fish collagen peptide. GPVGPS upregulates the expression of vascular endothelial growth factor (VEGF), PCNA, hepatocyte growth factor, epidermal growth factor (EGF) , and insulin-like growth factor 1 (IGF-1), and downregulates the expression of negative regulatory proteins associated with hair health. GPVGPS inhibits MMP-1, MMP-2, and MMP-9, increases skin water content, reduces wrinkles, and improves oxidative stress status and pro-inflammatory cytokine levels. GPVGPS can be used in studies related to hair loss and UVB-induced skin photoaging. | |||||||||||||||||||||
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References
- [1]. Koo J, et al. Gly-Pro-Val-Gly-Pro-Ser Low Molecular Weight Fish Collagen Peptide Promotes Hair Regeneration in Human Dermal Papilla Cells and C57BL/6 Mice. Journal of medicinal food. 2025 Dec;28(12):1225-1234.
- [2]. Cho W, et al. Gly-Pro-Val-Gly-Pro-Ser Peptide Fish Collagen Improves Skin Moisture and Wrinkles with Ameliorated the Oxidative Stress and Pro-inflammatory Factors in Skin Photoaging Mimic Models. Preventive nutrition and food science. 2023 Mar 31;28(1):50-60.
- [3]. Hwang SB, et al. Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors. Mar Drugs. 2023 Aug 29;21(9):475.
- [4]. Feng C, et al. Matrix Metalloproteinases on Skin Photoaging. Journal of cosmetic dermatology. 2024 Dec;23(12):3847-3862. [Content Brief]
