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Cat. No.: HY-P11890

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GPVGPS

GPVGPS is a low-molecular-weight fish collagen peptide. GPVGPS upregulates the expression of vascular endothelial growth factor (VEGF), PCNA, hepatocyte growth factor, epidermal growth factor (EGF) , and insulin-like growth factor 1 (IGF-1), and downregulates the expression of negative regulatory proteins associated with hair health. GPVGPS inhibits MMP-1, MMP-2, and MMP-9, increases skin water content, reduces wrinkles, and improves oxidative stress status and pro-inflammatory cytokine levels. GPVGPS can be used in studies related to hair loss and UVB-induced skin photoaging.

For research use only. We do not sell to patients.

CAS No.: 1154403-54-9
Formula: C₂₂H₃₆N₆O₈
Molecular Weight:512.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

GPVGPS Chemical Structure

CAS No.: 1154403-54-9

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

All VEGFR Isoforms :

All EGFR Isoforms :

All MMP Isoforms :

In Vitro

Oxidative StressCytokines & Chemokines

Oxidative Stress

Cytokines & Chemokines

GPVGPS (Gly-Pro-Val-Gly-Pro-Ser) fish collagen peptide protects HaCaT human keratinocytes against UVB-induced skin photoaging by downregulating MMP-1, MMP-2, and MMP-9, upregulating collagen-related markers, and enhancing antioxidant and anti-inflammatory responses^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1154403-54-9
Molecular Weight 512.56
Formula C₂₂H₃₆N₆O₈
Sequence

Gly-Pro-Val-Gly-Pro-Ser
Sequence Shortening

GPVGPS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Koo J, et al. Gly-Pro-Val-Gly-Pro-Ser Low Molecular Weight Fish Collagen Peptide Promotes Hair Regeneration in Human Dermal Papilla Cells and C57BL/6 Mice. Journal of medicinal food. 2025 Dec;28(12):1225-1234.

[2]. Cho W, et al. Gly-Pro-Val-Gly-Pro-Ser Peptide Fish Collagen Improves Skin Moisture and Wrinkles with Ameliorated the Oxidative Stress and Pro-inflammatory Factors in Skin Photoaging Mimic Models. Preventive nutrition and food science. 2023 Mar 31;28(1):50-60.

[3]. Hwang SB, et al. Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors. Mar Drugs. 2023 Aug 29;21(9):475.

[4]. Feng C, et al. Matrix Metalloproteinases on Skin Photoaging. Journal of cosmetic dermatology. 2024 Dec;23(12):3847-3862. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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GPVGPS

All VEGFR Isoforms

All EGFR Isoforms

All MMP Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Keywords

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GPVGPS

All VEGFR Isoforms

All EGFR Isoforms

All MMP Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GPVGPS Related Classifications

HY-P11890 Related Classifications

Bioz

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