1214099-39-4
Chemical Structure
(Rac)-VU0637120
- CAS No.: 1214099-39-4
- Formula:C16H19N3O5S2
- Molecular Weight:397.47
InChIKey: XLSQVBRMGFLMGL-UHFFFAOYSA-N
SMILES: O=C(C1N(S(=O)(C)=O)CCCC1)NC2=NC3=C(S2)C=C4OCCOC4=C3
Biological Activity: (Rac)-VU0637120 is the racemate of (S)-VU0637120 (HY-165125). (S)-VU0637120 is a selective Y4R antagonist that effectively reduces the binding of its endogenous ligand pancreatic polypeptide (PP) to Y4R, with an IC50 value of 2.7 μM. (S)-VU0637120 binds to an allosteric site of Y4R, which is located in the core region of the transmembrane structure of Y4R, near the binding pocket of pancreatic polypeptide (PP), with a KB of 380 nM. (Rac)-VU0637120 can be used for research on metabolic diseases[1].
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(Rac)-VU0637120 | (Rac)-VU0637120 is the racemate of (S)-VU0637120 (HY-165125). (S)-VU0637120 is a selective Y4R antagonist that effectively reduces the binding of its endogenous ligand pancreatic polypeptide (PP) to Y4R, with an IC50 value of 2.7 μM. (S)-VU0637120 binds to an allosteric site of Y4R, which is located in the core region of the transmembrane structure of Y4R, near the binding pocket of pancreatic polypeptide (PP), with a KB of 380 nM. (Rac)-VU0637120 can be used for research on metabolic diseases. | |||||||||||||||||||||
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