1217769-04-4
1217769-04-4
Chemical Structure
Pravastatin lactone-d3
- CAS No.: 1217769-04-4
- Formula:C23H31D3O6
- Molecular Weight:409.53
IUPAC Name: (1S,3S,7S,8S,8aR)-3-hydroxy-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-(methyl-d3)butanoate
InChIKey: OQARDMYXSOFTLN-BGFMQMSKSA-N
SMILES: O(C([C@H](CC)C([2H])([2H])[2H])=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@@H](O)C1)[H]
Biological Activity: Pravastatin Lactone-d3 is the deuterium labeled Pravastatin Lactone[1].
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Pravastatin lactone-d3 | Pravastatin Lactone-d3 is the deuterium labeled Pravastatin Lactone. | |||||||||||||||||||||
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Pravastatin lactone | 99.20% | Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis. | ||||||||||||||||||||
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L-157012 | L-157012 is a HMG-CoA reductase (HMGCR) inhibitor. L-157012 is also a cholesterol-lowering agent. | |||||||||||||||||||||
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2'-Ethyl Simvastatin | 2'-Ethyl Simvastatin (compound 6) is a Mevinolin analog, with HMG-CoA reductase inhibition. | |||||||||||||||||||||
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Simvastatin impurity 11 | Simvastatin impurity 11 is an impurity of Simvastatin. | |||||||||||||||||||||
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(Rac)-3′-Hydroxy simvastatin | (Rac)-3′-Hydroxy simvastatin is an isomer of 3′-Hydroxy simvastatin. 3′-Hydroxy simvastatin is an oxidative metabolite of Simvastatin (HY-17502) produced by hepatic CYP450 metabolism, and is also the major terminal metabolite of Simvastatin in rats. 3′-Hydroxy simvastatin possesses HMG-CoA Reductase inhibitory activity. 3′-Hydroxy simvastatin is used in metabolism-related research. | |||||||||||||||||||||
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3'-Hydroxy simvastatin | 99.71% | 3′-Hydroxy simvastatin is an oxidative metabolite of Simvastatin (HY-17502) produced by hepatic CYP450 metabolism, and is also the major terminal metabolite of Simvastatin in rats. 3′-Hydroxy simvastatin possesses HMG-CoA Reductase inhibitory activity. 3′-Hydroxy simvastatin is used in metabolism-related research. | ||||||||||||||||||||
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Keto lovastatin | Keto lovastatin (Monacolin X) is an impurity of Lovastatin (HY-N0504) and also a competitive inhibitor of HMG-CoA reductase. Keto lovastatin exerts its cholesterol-lowering effect by blocking the rate-limiting step of endogenous cholesterol synthesis. Keto lovastatin can be used in research on hypercholesterolemia and atherosclerosis, and can also serve as an impurity reference standard in the research on the production and quality control of Lovastatin. | |||||||||||||||||||||
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Mevastatin (Standard) | 98.95% | Mevastatin (Standard) is the analytical standard of Mevastatin. This product is intended for research and analytical applications. Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G0/G1 phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment. | ||||||||||||||||||||
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Simvastatin | 99.56% | Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. | ||||||||||||||||||||
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Lovastatin | 99.75% | Lovastatin (Mevinolin) is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol. | ||||||||||||||||||||
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