1218-98-0
1218-98-0
Chemical Structure
7,8-Dihydroneopterin
- CAS No.: 1218-98-0
- Formula:C9H13N5O4
- Molecular Weight:255.23
IUPAC Name: 2-amino-6-((1S,2R)-1,2,3-trihydroxypropyl)-7,8-dihydropteridin-4(3H)-one
InChIKey: YQIFAMYNGGOTFB-XINAWCOVSA-N
SMILES: O=C1NC(N)=NC2=C1N=C([C@H](O)[C@H](O)CO)CN2
Biological Activity: 7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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7,8-Dihydroneopterin | 97.2% | 7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases. | ||||||||||||||||||||
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7,8-Dihydroneopterin (Standard) | ≥98% | Sanguinarine (Standard) is the analytical standard of Sanguinarine. This product is intended for research and analytical applications. Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB. | ||||||||||||||||||||
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Tetrahydrobiopterin | Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms. | |||||||||||||||||||||
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L-Sepiapterin | 90.48% | L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia. | ||||||||||||||||||||
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Ronopterin | Ronopterin (VAS203) is a NO Synthase inhibitor. Ronopterin can be used in research on diseases of the urogenital system and the nervous system. | |||||||||||||||||||||
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Ganciclovir (Standard) | 99.77% | Ganciclovir (Standard) is the analytical standard of Ganciclovir. This product is intended for research and analytical applications. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain. | ||||||||||||||||||||
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Sapropterin-d3 | Sapropterin-d3 ((6R)-BH4-d3) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU). | |||||||||||||||||||||
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T7117 | T7117 is a TRIM25-HIF-1α inhibitor. T7117 disrupts the interaction between TRIM25-HIF-1α. T7117 can be used for the research of glioblastoma. | |||||||||||||||||||||
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Sapropterin | Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE). | |||||||||||||||||||||
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Sapropterin dihydrochloride | 99.61% | Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE). | ||||||||||||||||||||
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7,8-Dihydro-L-biopterin | 99.79% | 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases. | ||||||||||||||||||||
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(6R)-Tetrahydro-L-biopterin sulfate | (6R)-Tetrahydro-L-biopterin (sulfate) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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