122341-39-3
Chemical Structure
SQN400
Synonym(s): m-THPBC
- CAS No.: 122341-39-3
- Formula:C44H34N4O4
- Molecular Weight:682.78
IUPAC Name: 3,3',3'',3'''-(7H,8H,17H,18H-porphyrin-5,10,15,20-tetrayl)tetraphenol
InChIKey: JGRCJAZOAGUZAY-LWQDQPMZSA-N
SMILES: OC1=CC=CC(=C1)C=2C3=CC=C(N3)C(C=4C=CC=C(O)C4)=C5N=C(C(C=6C=CC=C(O)C6)=C7C=CC(N7)=C(C=8C=CC=C(O)C8)C9=NC2CC9)CC5
Biological Activity: SQN400 (m-THPBC) is a near-infrared Photosensitizer and singlet oxygen-mediated photodynamic tissue necrosis inducer. SQN400 is activated by near-infrared light at a wavelength of 740 nm. SQN400 exhibits a dose threshold in photodynamic liver necrosis, beyond which the extent of necrosis correlates with the light product. SQN400 induces full-thickness necrosis in implanted mouse colorectal tumors. SQN400 is used in the study of colorectal adenocarcinoma[1][2].
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SQN400 | SQN400 (m-THPBC) is a near-infrared Photosensitizer and singlet oxygen-mediated photodynamic tissue necrosis inducer. SQN400 is activated by near-infrared light at a wavelength of 740 nm. SQN400 exhibits a dose threshold in photodynamic liver necrosis, beyond which the extent of necrosis correlates with the light product. SQN400 induces full-thickness necrosis in implanted mouse colorectal tumors. SQN400 is used in the study of colorectal adenocarcinoma. | |||||||||||||||||||||
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References
- [1]. Rovers JP, et al. In vivo photodynamic characteristics of the near-infrared photosensitizer 5,10,15,20-tetrakis(M-hydroxyphenyl) bacteriochlorin. Photochemistry and photobiology. 2000 Sep;72(3):358-64.
- [2]. Palumbo G, et al. Photodynamic therapy and cancer: a brief sightseeing tour. Expert opinion on drug delivery. 2007 Mar;4(2):131-48.
