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Cat. No.: HY-19287

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SQN400

Name: SQN400
Brand: MedChemExpress
SKU: HY-19287
Availability: PreOrder

(Synonyms: m-THPBC)

SQN400 (m-THPBC) is a near-infrared Photosensitizer and singlet oxygen-mediated photodynamic tissue necrosis inducer. SQN400 is activated by near-infrared light at a wavelength of 740 nm. SQN400 exhibits a dose threshold in photodynamic liver necrosis, beyond which the extent of necrosis correlates with the light product. SQN400 induces full-thickness necrosis in implanted mouse colorectal tumors. SQN400 is used in the study of colorectal adenocarcinoma.

For research use only. We do not sell to patients.

CAS No.: 122341-39-3
Formula: C₄₄H₃₄N₄O₄
Molecular Weight:682.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SQN400 Chemical Structure

CAS No.: 122341-39-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
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Biological Activity

Description

In Vivo

Anti-cancerOthers

Anti-cancer

SQN400 (1.2 mg/kg; i.v.; once; 24 h before irradiation) undergoes rapid in vivo photobleaching in Colo26 tumors in BALB/c mice and, in combination with 739 nm light, produces full-thickness tumor necrosis^[1].

Others

SQN400 (0.5 mg/kg; once; 24 h before irradiation) is optimally activated in normal Wistar rat liver under 738.9 nm near-infrared light^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female adult)^[1]
Dosage:

1.2 mg/kg
Administration:

i.v. (tail vein); once; 24 h before irradiation
Result:

Bleached rapidly, with almost no photosensitizer fluorescence detectable from the tumor surface after 30 s of irradiation.
Showed an initial bleaching rate approximately 20 times greater than that of mTHPC under similar conditions.
Produced full-thickness tumor necrosis in all animals at 1.2 mg/kg with 3 J cm^-2 of 739 nm light 24 h after administration, with tumor thickness ranging from 3.7 to 5.0 mm.

Chemical Information

CAS No. 122341-39-3
Molecular Weight 682.78
Formula C₄₄H₃₄N₄O₄
SMILES

OC1=CC=CC(=C1)C=2C3=CC=C(N3)C(C=4C=CC=C(O)C4)=C5N=C(C(C=6C=CC=C(O)C6)=C7C=CC(N7)=C(C=8C=CC=C(O)C8)C9=NC2CC9)CC5
Synonyms

m-THPBC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rovers JP, et al. In vivo photodynamic characteristics of the near-infrared photosensitizer 5,10,15,20-tetrakis(M-hydroxyphenyl) bacteriochlorin. Photochemistry and photobiology. 2000 Sep;72(3):358-64.

[2]. Palumbo G, et al. Photodynamic therapy and cancer: a brief sightseeing tour. Expert opinion on drug delivery. 2007 Mar;4(2):131-48.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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