1227698-30-7
Chemical Structure
Hercynylcysteine sulfoxide
- CAS No.: 1227698-30-7
- Formula:C12H20N4O5S
- Molecular Weight:332.38
InChIKey: CSTNDZVKJNPMIG-PTZMPWRZSA-N
SMILES: C[N+](C)(C)[C@H](C([O-])=O)CC1=CN=C(S(C[C@H](N)C(O)=O)=O)N1
Biological Activity: Hercynylcysteine sulfoxide is a synthetic precursor of Ergothioneine (HY-N1914), and it spontaneously converts to Ergothioneine in the presence of pyridoxal phosphate (PLP). Hercynylcysteine sulfoxide is produced via the fusion enzyme complex NcEgt1‑1/CtEgtB-catalyzed conversion of L-histidine and L-cysteine, and serves as an intermediate in the ergothioneine biosynthetic pathway of Schizosaccharomyces pombe and engineered Escherichia coli BL21 (DE3)[1][2].
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Hercynylcysteine sulfoxide | Hercynylcysteine sulfoxide is a synthetic precursor of Ergothioneine (HY-N1914), and it spontaneously converts to Ergothioneine in the presence of pyridoxal phosphate (PLP). Hercynylcysteine sulfoxide is produced via the fusion enzyme complex NcEgt1‑1/CtEgtB-catalyzed conversion of L-histidine and L-cysteine, and serves as an intermediate in the ergothioneine biosynthetic pathway of Schizosaccharomyces pombe and engineered Escherichia coli BL21 (DE3). | |||||||||||||||||||||
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References
- [1]. Pluskal T, et al. Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system. PloS one. 2014;9(5):e97774. [Content Brief]
- [2]. Li L, et al. Efficient production of Ergothioneine via an optimized allogenous assembly of the ERG synthesis pathway in Escherichia coli BL21. Journal of biotechnology. 2025 Oct;406:13-23.
