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Cat. No.: HY-189490

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Hercynylcysteine sulfoxide

Hercynylcysteine sulfoxide is a synthetic precursor of Ergothioneine (HY-N1914), and it spontaneously converts to Ergothioneine in the presence of pyridoxal phosphate (PLP). Hercynylcysteine sulfoxide is produced via the fusion enzyme complex NcEgt1‑1/CtEgtB-catalyzed conversion of L-histidine and L-cysteine, and serves as an intermediate in the ergothioneine biosynthetic pathway of Schizosaccharomyces pombe and engineered Escherichia coli BL21 (DE3).

For research use only. We do not sell to patients.

CAS No.: 1227698-30-7
Formula: C₁₂H₂₀N₄O₅S
Molecular Weight:332.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hercynylcysteine sulfoxide Chemical Structure

CAS No.: 1227698-30-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Protein/Amino Acid Metabolism

Hercynylcysteine sulfoxide is undetectable in wild-type Schizosaccharomyces pombe cells under vegetative growth conditions; it accumulates in egt2Δ deletion mutant Schizosaccharomyces pombe cells cultured under vegetative growth, nitrogen starvation, or glucose starvation conditions for 24 hours^[1].
Hercynylcysteine sulfoxide accumulates in Schizosaccharomyces pombe egt1⁺ overexpression strains in a promoter strength-dependent manner under thiamine-free culture conditions; it accumulates in large quantities in Schizosaccharomyces pombe P3nmt1-egt1⁺ Δegt2 double mutant cells cultured in selenium-supplemented medium^[1].
Hercynylcysteine sulfoxide is a transient biosynthetic intermediate produced by engineered Escherichia coli BL21 (DE3) via a two-step consecutive enzymatic reaction involving NcEgt1-1 and CtEgtB^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1227698-30-7
Molecular Weight 332.38
Formula C₁₂H₂₀N₄O₅S
SMILES

C[N+](C)(C)[C@H](C([O-])=O)CC1=CN=C(S(C[C@H](N)C(O)=O)=O)N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pluskal T, et al. Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system. PloS one. 2014;9(5):e97774. [Content Brief]

[2]. Li L, et al. Efficient production of Ergothioneine via an optimized allogenous assembly of the ERG synthesis pathway in Escherichia coli BL21. Journal of biotechnology. 2025 Oct;406:13-23.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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