1240687-76-6
Chemical Structure
S-palm P0(180–199)
- CAS No.: 1240687-76-6
- Formula:C112H191N33O29S2
- Molecular Weight:2528.05
SMILES: O=C(N[C@@H](CSC(CCCCCCCCCCCCCCC)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Biological Activity: S-palm P0(180-199) is an S-palmitoylated peptide derived from P0 protein. S-palm P0(180-199) induces IL-17+ cells, macrophage infiltration, and anti-P0 antibodies. S-palm P0(180-199) induces chronic inflammatory demyelinating polyneuropathy in rats via active immunization, manifesting as a relapsing-remitting disease driven by persistent T cells, macrophages, Th17 cells and related cytokines, and P0-specific IgG. S-palm P0(180-199) can be used in research related to chronic inflammatory demyelinating polyneuropathy[1][2][3].
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S-palm P0(180–199) | S-palm P0(180-199) is an S-palmitoylated peptide derived from P0 protein. S-palm P0(180-199) induces IL-17+ cells, macrophage infiltration, and anti-P0 antibodies. S-palm P0(180-199) induces chronic inflammatory demyelinating polyneuropathy in rats via active immunization, manifesting as a relapsing-remitting disease driven by persistent T cells, macrophages, Th17 cells and related cytokines, and P0-specific IgG. S-palm P0(180-199) can be used in research related to chronic inflammatory demyelinating polyneuropathy. | |||||||||||||||||||||
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References
- [1]. Brun S, et al. An autophagy-targeting peptide to treat chronic inflammatory demyelinating polyneuropathies. Journal of autoimmunity. 2018 Aug;92:114-125.
- [2]. Brun S, et al. Assessing Autophagy in Sciatic Nerves of a Rat Model that Develops Inflammatory Autoimmune Peripheral Neuropathies. Cells. 2017 Sep 18;6(3):30.
- [3]. Brun S, et al. Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies. Journal of neuroimmunology. 2015 Jan 15;278:1-10.
