S-palm P0(180–199)
Based on 1 publication(s) in Google Scholar
S-palm P0(180-199) is an S-palmitoylated peptide derived from P0 protein. S-palm P0(180-199) induces IL-17+ cells, macrophage infiltration, and anti-P0 antibodies. S-palm P0(180-199) induces chronic inflammatory demyelinating polyneuropathy in rats via active immunization, manifesting as a relapsing-remitting disease driven by persistent T cells, macrophages, Th17 cells and related cytokines, and P0-specific IgG. S-palm P0(180-199) can be used in research related to chronic inflammatory demyelinating polyneuropathy.
For research use only. We do not sell to patients.
- CAS No.: 1240687-76-6
- Formula: C112H191N33O29S2
- Molecular Weight:2528.05
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) S-palm P0(180–199)
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Biological Activity
Description
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IL-4 |
IL-10 |
IL-17 |
In Vitro
S-palm P0(180-199) restimulation of LNC from immunized Lewis rats shows elevated levels of IFN-γ, IL-4, IL-10, and IL-17 in the supernatant at 18 dpi, with sustained IL-17 production still detectable at 57 dpi[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lewis (male, 7-8 weeks, 250-270 g)[1]
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Dosage:200 μg per rat
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Administration:s.c.; single immunization
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Result:Induced chronic experimental autoimmune neuritis with progressive anti-P0(180-199) IgG antibody responses.
Caused marked reduction of myelinated fibers at 18 dpi.
Induced numerous small-diameter myelinated fibers at 60 dpi.
Induced clustered small-diameter axons at 60 dpi.
Induced macrophage accumulation in sciatic nerves at 60 dpi.
Induced highly significant accumulation of IL-17+ cells in spinal nerve roots at 60 dpi (approximately 130 IL-17+ cells/mm2).
Decreased MAP1LC3B-II and increased SQSTM1 in sciatic nerves.
Decreased MAP1LC3B-I/II+ Schwann cells.
Induced accumulation of SQSTM1+ macrophages and increased LAMP2A expression in sciatic nerve macrophages at 18 and 60 dpi.
Elevated serum IL-17 levels in the late phase of disease.
Elevated TNF at 18 dpi and IFNγ at 60 dpi.
Reduced IL-4 at 60 dpi.
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Animal Model:Lewis rats (male, 7-8 weeks old, 250-270 g)[2]
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Dosage:200 µg
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Administration:s.c.; once
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Result:Induced CIDP with a clinical score of 3 (severe paraparesis).
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Animal Model:Lewis (male, 7-8 weeks old, 230-250 g, chronic experimental autoimmune neuritis induced by active immunization with S-palmitoylated P0(180-199) peptide in CFA)[3]
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Dosage:200 μg per rat
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Administration:s.c.; single immunization
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Result:Induced chronic disease with onset at 11.5 dpi and maximal clinical score of 3.7 at day 17.
Induced chronic clinical signs in 5 rats up to day 74.
Induced complete recovery in 7 rats by 28.5 dpi followed by relapse at 38 dpi.
Reduced SNCV at 18 dpi to 37 m/s with no recovery at 43 dpi (36 m/s) or 57 dpi (34 m/s).
Reduced CMAP amplitude at 18 dpi to 1.0 mV, increased to 30.6 mV at 43 dpi, and reduced to 10.2 mV at 57 dpi.
Increased CMAP latency at 57 dpi to 2.1 ms compared to 1.3 ms at 3 dpi.
Induced clustered myelinated axons of small diameter and persistent T lymphocytes and macrophages in sciatic nerves at 74 dpi.
Increased IL-17+ cells in spinal nerve roots.
Elevated IFN-γ, IL-4, and IL-10 levels in LNC at 18 dpi.
Increased IL-17 levels in LNC at 18 and 43 dpi.
Elevated serum IL-17 levels at all timepoints.
Maintained high serum antibody levels at 57 dpi.
Chemical Information
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CAS No. 1240687-76-6
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Molecular Weight 2528.05
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Formula C112H191N33O29S2
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Sequence
Ala-{Cys(Palm)}-Lys-Arg-Gly-Arg-Gln-Thr-Pro-Val-Leu-Tyr-Ala-Met-Leu-Asp-His-Ser-Arg-Ser
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Sequence Shortening
A-{Cys(Palm)}-KRGRQTPVLYAMLDHSRS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Heliyon
Lactobacillus rhamnosus ameliorates experimental autoimmune neuritis via modulation of gut microbiota and metabolites. [Abstract]2024 Oct 9;10(21):e39126. PMID: 39524841
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
S-palm P0(180–199) Related Classifications
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