1243603-61-3
1243603-61-3
Chemical Structure
V-ATPase-IN-1
- CAS No.: 1243603-61-3
- Formula:C21H20ClNO2
- Molecular Weight:353.84
InChIKey: OWIHKEZYFBVCNY-UHFFFAOYSA-N
SMILES: ClC1=CC(CNC2=CC=CC=C2)=CC(OC)=C1OCC3=CC=CC=C3
Biological Activity: V-ATPase-IN-1 (Compound 3b-03) is a Vacuolar-type H+-ATPases (V-ATPase) inhibitor (IC50 = 194.80 μM) that can effectively target the V-ATPase subunit A (Kd = 0.803 μM). V-ATPase-IN-1 exhibits insecticidal activity against M. separata (LC50 = 2.64 mM) and contributes to research in the development of chemical insecticides[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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V-ATPase-IN-1 | 99.23% | V-ATPase-IN-1 (Compound 3b-03) is a Vacuolar-type H+-ATPases (V-ATPase) inhibitor (IC50 = 194.80 μM) that can effectively target the V-ATPase subunit A (Kd = 0.803 μM). V-ATPase-IN-1 exhibits insecticidal activity against M. separata (LC50 = 2.64 mM) and contributes to research in the development of chemical insecticides. | ||||||||||||||||||||
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Pocapavir (Standard) | ≥98% | Pocapavir (Standard) is the analytical standard of Pocapavir (HY-104074). This product is intended for research and analytical applications. Pocapavir (SCH-48973) is an orally active capsid inhibitor. Pocapavir prevents virion uncoating upon entry into the cell. Pocapavir has antiviral activity against polioviruses. Pocapavir also inhibits enterovirus infections. | ||||||||||||||||||||
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ML358 | ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC50=0.24 μM). ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics. | |||||||||||||||||||||
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Benzyl 2-naphthyl ether | 99.44% | Benzyl 2-naphthyl ether is a compound mentioned in the study of the effects of aromatic sensitizers on zebrafish embryos. It can cause morphological abnormalities and changes in gene expression in zebrafish embryos. Its toxicity mechanism is partly related to AHR, and there may be other mechanisms independent of AHR. | ||||||||||||||||||||
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HDAC8-IN-8 | 95.0% | HDAC8-IN-8 (15a) is an HDAC8 inhibitor, with IC50 values of 23.9 μM and 268.2 μM for hHDAC8 and smHDAC8 respectively. And for hHDAC1 and hHDAC6, the IC50 values are 12.1 μM and 2.9 μM respectively. HDAC8-IN-8 can be used in schistosomiasis-related research. | ||||||||||||||||||||
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MAO-B-IN-22 | MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC50 of 0.014 μM. MAO-B-IN-22 has high antioxidant activity, good metal chelating ability, proper BBB permeability and significant neuroprotective effect. | |||||||||||||||||||||
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AK-42 | AK-42 is a selective CLC-2 chloride channel inhibitor with human IC50 of 17 nM and rat IC50 of 14 nM. AK-42 binds to an extracellular vestibule above the channel pore, inhibits CLC-2 currents acutely and reversibly, including with auxiliary subunit GlialCAM coexpression. AK-42 acts as a selective tool compound for acute CLC-2 function modulation to probe CLC-2 neurophysiology. AK-42 can be used for the research of leukodystrophy and idiopathic generalized epilepsies. | |||||||||||||||||||||
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Rev1-CT/RIR PPI-IN-2 | Rev1-CT/RIR PPI-IN-2 (compound 10) is a Rev1-CT/RIR protein-protein interaction inhibitor.Rev1-CT/RIR PPI-IN-2 enhances cisplatin-mediated cell killing. | |||||||||||||||||||||
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N-Benzylaniline | 99.88% | N-Benzylaniline (N-Phenylbenzylamine) is an N-alkylated derivative of aniline. | ||||||||||||||||||||
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XIE62-1004-A | 99.92% | XIE62-1004-A is an inducer of p62-LC3 interaction. XIE62-1004-A can bind to the ZZ-domain of p62, inducing p62 oligomerization and activating p62-dependent autophagy. | ||||||||||||||||||||
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2,5-Bis(benzyloxy)terephthalic acid | 2,5-Bis(benzyloxy)terephthalic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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