126144-46-5
Chemical Structure
CD4 (81-92) (human)
- CAS No.: 126144-46-5
- Formula:C62H96N14O26S
- Molecular Weight:1485.57
InChIKey: AZDASIIAIPAELA-UCEFLIQFSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@@H](N)[C@H](O)C)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CS)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: CD4 (81-92) (human) is a fragment of hCD4. CD4 (81-92) (human) can undergo structural modifications including derivatization and cyclization to enhance antiviral potency and stability, with sequence alterations affecting its activity. CD4 (81-92) (human) is applicable to studies related to HIV-1 infection[1][2].
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CD4 (81-92) (human) | CD4 (81-92) (human) is a fragment of hCD4. CD4 (81-92) (human) can undergo structural modifications including derivatization and cyclization to enhance antiviral potency and stability, with sequence alterations affecting its activity. CD4 (81-92) (human) is applicable to studies related to HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Rausch DM, et al. CD4(81-92)-based peptide derivatives. Structural requirements for blockade of HIV infection, blockade of HIV-induced syncytium formation, and virostatic activity in vitro. Biochem Pharmacol. 1992 Apr 15;43(8):1785-96. [Content Brief]
- [2]. Lifson JD, et al. Synthetic peptides allow discrimination of structural features of CD4(81-92) important for HIV-1 infection versus HIV-1-induced syncytium formation. AIDS research and human retroviruses. 1991 Jun;7(6):521-7. [Content Brief]
