1309199-66-3
1309199-66-3
Chemical Structure
CHVB-032
- CAS No.: 1309199-66-3
- Formula:C18H22FN5O
- Molecular Weight:343.40
InChIKey: JPNYHGLTCZIFDD-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC1)C2=NC(NCC)=NC(C)=C2)C3=CC=C(C=C3)F
Biological Activity: CHVB-032 is an antiviral agent and SFV nsP1 inhibitor. CHVB-032 inhibits the methyltransferase and guanylyltransferase activities of nsP1, blocks viral RNA capping process, and suppresses post-entry steps in CHIKV replication. CHVB-032 inhibits CHIKV replication across different isolates, but shows no activity against other alphaviruses. CHVB-032 can be used in research related to chikungunya fever and CHIKV infection[1][2][3].
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CHVB-032 | CHVB-032 is an antiviral agent and SFV nsP1 inhibitor. CHVB-032 inhibits the methyltransferase and guanylyltransferase activities of nsP1, blocks viral RNA capping process, and suppresses post-entry steps in CHIKV replication. CHVB-032 inhibits CHIKV replication across different isolates, but shows no activity against other alphaviruses. CHVB-032 can be used in research related to chikungunya fever and CHIKV infection. | |||||||||||||||||||||
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References
- [1]. Doctoral Thesis, et al. Chikungunya virus nonstructural protein 1 as an antiviral target. Leiden University. 2021.
- [2]. Abdelnabi R, et al. Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery. Antimicrob Agents Chemother. 2020;64(7):e00649-20. Published 2020 Jun 23. [Content Brief]
- [3]. Kovacikova K, et al. Small-Molecule Inhibitors of Chikungunya Virus: Mechanisms of Action and Antiviral Drug Resistance. Antimicrob Agents Chemother. 2020;64(12):e01788-20. Published 2020 Nov 17. [Content Brief]
