13146-72-0
13146-72-0
Chemical Structure
3'-Deoxyinosine
- CAS No.: 13146-72-0
- Formula:C10H12N4O4
- Molecular Weight:252.23
IUPAC Name: 7-ethynylindoline-2,3-dione
InChIKey: RPZDLTVHZJHPAW-BAJZRUMYSA-N
SMILES: O=C1C2=C(N([C@H]3[C@H](O)C[C@@H](CO)O3)C=N2)N=CN1
Biological Activity: 3'-Deoxyinosine is an antiprotozoal purine nucleoside and a metabolite of Cordycepin (HY-N0262). 3'-Deoxyinosine inhibits inflammatory gene expression. 3'-Deoxyinosine inhibits the growth of Leishmania tropica promastigotes. 3'-Deoxyinosine can be used in research on cutaneous leishmaniasis[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3'-Deoxyinosine | 99.88% | 3'-Deoxyinosine is an antiprotozoal purine nucleoside and a metabolite of Cordycepin (HY-N0262). 3'-Deoxyinosine inhibits inflammatory gene expression. 3'-Deoxyinosine inhibits the growth of Leishmania tropica promastigotes. 3'-Deoxyinosine can be used in research on cutaneous leishmaniasis. | ||||||||||||||||||||
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References
- [1]. Moorman AR, et al. Antiprotozoal activity of 3′-deoxyinosine: Inverse correlation to cleavage of the glycosidic bond. Biochemical pharmacology. 1991 Jul 5;42(2):207-12.
- [2]. Lee JB, et al. A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin. Scientific reports. 2019 Oct 31;9(1):15760.
- [3]. Lee SC, et al. Cordycepin (3'-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner. Cancers. 2022 Jun 25;14(13):3122.
- [4]. Rabie AM, et al. Potent Inhibitory Activities of the Adenosine Analogue Cordycepin on SARS-CoV-2 Replication. ACS omega. 2022 Jan 25;7(3):2960-2969. [Content Brief]
- [5]. Wataya Y, et al. 3′-Deoxyinosine as an anti-leishmanial agent: The metabolism and cytotoxic effects of 3′-deoxyinosine in Leishmaniatropica promastigotes. Biochemical and Biophysical Research Communications. 1984 Sep 17;123(2):677-83.
