133410-84-1
133410-84-1
Chemical Structure
Z-LLY-FMK
Synonym(s): Calpain Inhibitor IV
- CAS No.: 133410-84-1
- Formula:C30H40FN3O6
- Molecular Weight:557.65
IUPAC Name: benzyl ((S)-1-(((S)-1-(((S)-4-fluoro-1-(4-hydroxyphenyl)-3-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate
InChIKey: JCRSHQCFRMCMOC-GSDHBNRESA-N
SMILES: O=C(CF)[C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)CC(C=C2)=CC=C2O
Biological Activity: Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Z-LLY-FMK | 98.65% | Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis. | ||||||||||||||||||||
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MG-115 | 99.61% | MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis. | ||||||||||||||||||||
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Z-Glu-Tyr-OH | 99.42% | Z-Glu-Tyr-OH can be used for synthesis of peptides on a solid support. | ||||||||||||||||||||
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Z-LLF-CHO | Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor. | |||||||||||||||||||||
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Z-YVAD-FMK | 98.0% | Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities. | ||||||||||||||||||||
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[D-Ala2] Leu-Enkephalinamide | [D-Ala2] Leu-Enkephalinamide is an enkephalin analog. [D-Ala2] Leu-Enkephalinamide has great corneal permeability and analgesic effect. [D-Ala2] Leu-Enkephalinamide can be used for the research of ocular diseases. | |||||||||||||||||||||
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Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine | 99.78% | Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is a blood pressure lowering peptide containing 4 amino acids. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is an angiotensin-converting Enzyme (ACE) inhibitor. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine can be used in research of high blood pressure. | ||||||||||||||||||||
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Z-Leu-Leu-Tyr-COCHO | Z-Leu-Leu-Tyr-COCHO is a potent chymotrypsin-like activity inhibitor with a Ki value of 3.0 nM. | |||||||||||||||||||||
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Z-Leu-Tyr-Chloromethylketone | Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor. | |||||||||||||||||||||
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Z-Leu-Leu-Leu-fluoromethyl ketone | Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge. | |||||||||||||||||||||
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Z-YVAD-CMK | Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor. | |||||||||||||||||||||
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References
- [1]. Sheen-Chen SM, et al. Z-LLY-FMK can attenuate hepatocyte apoptosis after bile duct ligation in rat. Dig Dis Sci. 2008 Nov;53(11):2975-9. [Content Brief]
- [2]. Baig S, et al. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrob Agents Chemother. 2006 Aug;50(8):2886-8. [Content Brief]
- [3]. Kashio Y, et al. Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. J Immunol. 2003 Apr 1;170(7):3631-6. [Content Brief]
