1334532-23-8
1334532-23-8
Chemical Structure
Isovalerylcarnitine-d9 chloride
- CAS No.: 1334532-23-8
- Formula:C12H15D9ClNO4
- Molecular Weight:290.83
IUPAC Name: tert-butyl (R)-3-(piperidin-3-yl)azetidine-1-carboxylate
InChIKey: HWDFIOSIRGUUSM-UGYZPRMBSA-N
SMILES: CC(C)CC(O[C@H](CC(O)=O)C[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O.[Cl-]
Biological Activity: Isovalerylcarnitine-d9 chloride is the deuterium labeled Isovalerylcarnitine chloride (HY-145542). Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine chloride can specifically activate calpain in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isovalerylcarnitine-d9 chloride | Isovalerylcarnitine-d9 chloride is the deuterium labeled Isovalerylcarnitine chloride (HY-145542). Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine chloride can specifically activate calpain in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk. | |||||||||||||||||||||
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Isovalerylcarnitine chloride (Standard) | ≥98% | Isovalerylcarnitine chloride (Standard) is the analytical standard of Isovalerylcarnitine chloride (HY-145542). This product is intended for research and analytical applications. Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine can specifically activate calpain in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk. | ||||||||||||||||||||
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Isovalerylcarnitine-d9-1 chloride | 99.55% | Isovalerylcarnitine-d9-1 (chloride) is deuterium labeled Isovalerylcarnitine (chloride). Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils. | ||||||||||||||||||||
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Isovalerylcarnitine chloride | 99.48% | Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine chloride can specifically activate calpain in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk. | ||||||||||||||||||||
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(±)-Hexanoylcarnitine chloride | 98.0% | (±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways. | ||||||||||||||||||||
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Propionyl-DL-carnitine chloride | 98.10% | Propionyl-DL-carnitine chloride is a carnitine derivative. Propionyl-DL-carnitine chloride can be used for the research of inflammation. | ||||||||||||||||||||
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3-Methylglutarylcarnitine | 99% | 3-Methylglutarylcarnitine is a biomarker of disease associated with compromised mitochondrial energy metabolism. | ||||||||||||||||||||
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Isobutyryl-L-carnitine chloride (Standard) | ≥98% | Isobutyryl-L-carnitine chloride (Standard) is the analytical standard of Isobutyryl-L-carnitine chloride (HY-113165A). This product is intended for research and analytical applications. Isobutyryl-L-carnitine chloride is a biomarker. Isobutyryl-L-carnitine chloride is a product of acyl-CoA dehydrogenases involved in fatty acid β-oxidation, and it buffers the mitochondrial acyl-CoA/CoA ratio, oxidizes branched-chain amino acids, and supports the endogenous antioxidant defense system. Isobutyryl-L-carnitine chloride is a plasma biomarker of hepatic OCT1 transporter inhibition. Isobutyryl-L-carnitine chloride is a urinary biomarker of renal cell carcinoma, and its levels are elevated one year after nephrectomy compared with before nephrectomy. Isobutyryl-L-carnitine chloride can be used in research on renal cell carcinoma. | ||||||||||||||||||||
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Isovalerylcarnitine | 99.91% | Isovalerylcarnitine is a metabolite of leucine. Isovalerylcarnitine can specifically activate calpain in human neutrophils. Isovalerylcarnitine inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine are negatively correlated with reduced lung cancer risk. | ||||||||||||||||||||
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Butyryl-L-carnitine chloride | 99.55% | Butyryl-L-carnitine chloride is an acylcarnitine that can be isolated from Plasma/Serum. | ||||||||||||||||||||
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Hexanoyl-L-carnitine chloride | 99.61% | Hexanoyl-L-carnitine (chloride) is an ester product. | ||||||||||||||||||||
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Valeryl-L-carnitine chloride | Valeryl-L-carnitine (chloride) is an ester product. | |||||||||||||||||||||
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Malonyl-L-Carnitine chloride | Malonyl-L-Carnitine (chloride) is an ester product. | |||||||||||||||||||||
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Levocarnitine propionate hydrochloride | 95.0% | Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride) is used to study diseases such as renal function deterioration, congestive heart failure, and intermittent claudication. | ||||||||||||||||||||
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References
- [1]. Smith-Byrne K, et al. Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements. Cancer Epidemiol Biomarkers Prev. 2022;31(10):1966-1974. [Content Brief]
- [2]. Pontremoli S, et al. Isovalerylcarnitine is a specific activator of calpain of human neutrophils. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1189-95. [Content Brief]
