1360168-37-1
Chemical Structure
N-De-phenylethyl isohericerin
Synonym(s): NDPIH
- CAS No.: 1360168-37-1
- Formula:C19H25NO3
- Molecular Weight:315.41
IUPAC Name: (E)-5-(3,7-dimethylocta-2,6-dien-1-yl)-4-hydroxy-6-methoxyisoindolin-1-one
InChIKey: AXUYTAQZPXNVBF-MDWZMJQESA-N
SMILES: OC1=C2C(=CC(OC)=C1C/C=C(/CCC=C(C)C)\C)C(=O)NC2
Biological Activity: N-De-phenylethyl isohericerin (NDPIH) is a neurotrophic agent and ERK1/2 activator. N-De-phenylethyl isohericerin activates ERK1/2 signaling in a TrkB-independent manner, and its effects are partially mediated through BDNF/TrkB signaling. N-De-phenylethyl isohericerin promotes axon growth, neurite branching, and growth cone enlargement in central neurons, and enhances memory. N-De-phenylethyl isohericerin can be used for research on neurological diseases[1][2][3][4].
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N-De-phenylethyl isohericerin | N-De-phenylethyl isohericerin (NDPIH) is a neurotrophic agent and ERK1/2 activator. N-De-phenylethyl isohericerin activates ERK1/2 signaling in a TrkB-independent manner, and its effects are partially mediated through BDNF/TrkB signaling. N-De-phenylethyl isohericerin promotes axon growth, neurite branching, and growth cone enlargement in central neurons, and enhances memory. N-De-phenylethyl isohericerin can be used for research on neurological diseases. | |||||||||||||||||||||
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References
- [1]. Taib NAB, et al. Application of Medicinal Mushrooms for the Treatment of Peripheral Nerve Injury: A Systematic Review. Medical sciences (Basel, Switzerland). 2026 Jan 16;14(1):42.
- [2]. Martínez-Mármol R, et al. Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory[J]. bioRxiv, 2020: 2020.08. 28.271676.
- [3]. Martínez-Mármol R, et al. Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. Journal of neurochemistry. 2023 Jun;165(6):791-808. [Content Brief]
- [4]. Cipriano G L, et al. Beyond Neurotrophins: A Proposed Neurotrophic–Epigenetic Axis Mediated by Non-Coding RNA Networks for Hericium erinaceus Bioactives—A Hypothesis-Driven Review[J]. International Journal of Molecular Sciences, 2026, 27(3): 1269.
