N-De-phenylethyl isohericerin

N-De-phenylethyl isohericerin (10 μg/mL; 24 h) induces a potent neurotrophic effect in E18 Sprague Dawley rat hippocampal neurons cultured in serum-containing medium, increasing axon length 3-fold at a concentration of 10 μg/mL^[2].
N-De-phenylethyl isohericerin (1 μg/mL; 24 h) increases growth cone area 3-fold in E18 Sprague Dawley rat hippocampal neurons cultured in serum-containing medium at a concentration of 1 μg/mL, inducing enlarged growth cones with intact cytoskeletal organization^[2].
N-De-phenylethyl isohericerin (0.1-10 μg/mL; 24 h) directly induces concentration-dependent neurite outgrowth in low-density, serum-free E18 Sprague Dawley rat hippocampal neurons, with the greatest effect observed at 10 μg/mL^[2].
N-De-phenylethyl isohericerin (NDPIH) (10 μg/mL; 24 h) exerts potent neurotrophic activity in primary embryonic rat hippocampal neurons (serum-containing culture), increasing neurite length 3-fold and boosting neurite branching at a concentration of 10 μg/mL for 24 h^[3].
N-De-phenylethyl isohericerin (NDPIH) (1 μg/mL; 24 h) increases growth cone size 2- to 5-fold and alters cytoskeletal architecture in primary embryonic rat hippocampal neurons when applied at 1 μg/mL for 24 h^[3].
N-De-phenylethyl isohericerin (NDPIH) (0.1-10 μg/mL; 24 h) directly promotes concentration-dependent neurite outgrowth in low-density, serum-free primary embryonic rat hippocampal neurons, with maximal effects observed at 10 μg/mL for 24 h^[3].
N-De-phenylethyl isohericerin (NDPIH) (10 μg/mL; 24 h)-induced neurite outgrowth in low-density, serum-free primary embryonic rat hippocampal neurons is only partially mediated by the TrkB pathway, as co-treatment with 0.5 μM ANA-12 for 24 h reduces but does not eliminate the neurotrophic effect of 10 μg/mL NDPIH^[3].
N-De-phenylethyl isohericerin (NDPIH) (10 μg/mL; 1 h) activates ERK1/2 signaling independently of TrkB in TrkB-null HEK-293T cells when applied at 10 μg/mL for 1 h^[3].
N-De-phenylethyl isohericerin (NDPIH) (10 μg/mL; 1 h) activates ERK1/2 signaling in TrkB and p75 intracellular domain-co-transfected HEK-293T cells when applied at 10 μg/mL for 1 h, with no additional potentiation when combined with 1 ng/mL BDNF^[3].
N-De-phenylethyl isohericerin (NDPIH) (0.1-500 μg/mL) does not directly modulate TrkB kinase activity in cell-free assays at concentrations ranging from 0.1 to 500 μg/mL^[3].