137031-56-2
Chemical Structure
Litebamine
- CAS No.: 137031-56-2
- Formula:C20H21NO4
- Molecular Weight:339.39
IUPAC Name: 9,11-dimethoxy-2-methyl-1,2,3,4-tetrahydronaphtho[2,1-f]isoquinoline-8,12-diol
InChIKey: QOWFEPGZJDCIKG-UHFFFAOYSA-N
SMILES: OC(C=C1C=CC2=C(CCN(C3)C)C3=C4O)=C(OC)C=C1C2=C4OC
Biological Activity: Litebamine is a phenanthrene alkaloid with antiplatelet activity. Litebamine potently targets arachidonic acid- and collagen-induced platelet aggregation, but shows no activity against thrombin-induced aggregation. Litebamine inhibits arachidonic acid- and collagen-induced ATP release and thromboxane B2 production in rabbit platelets, without altering cyclic AMP levels or phosphoinositide breakdown in rabbit platelets. Litebamine has no effect on platelet-activating factor- or U46619 (HY-108566)-induced aggregation, nor does it affect [3H] inositol monophosphate production in rabbit platelets induced by collagen, platelet-activating factor or thrombin[1][2].
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Litebamine | Litebamine is a phenanthrene alkaloid with antiplatelet activity. Litebamine potently targets arachidonic acid- and collagen-induced platelet aggregation, but shows no activity against thrombin-induced aggregation. Litebamine inhibits arachidonic acid- and collagen-induced ATP release and thromboxane B2 production in rabbit platelets, without altering cyclic AMP levels or phosphoinositide breakdown in rabbit platelets. Litebamine has no effect on platelet-activating factor- or U46619 (HY-108566)-induced aggregation, nor does it affect [3H] inositol monophosphate production in rabbit platelets induced by collagen, platelet-activating factor or thrombin. | |||||||||||||||||||||
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References
- [1]. Teng CM, et al. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. The Journal of pharmacy and pharmacology. 1997 Jul;49(7):706-11. [Content Brief]
- [2]. Wu Y C, et al. Litebamine, a novel phenanthrene alkaloid from Litsea cubeba[J]. Tetrahedron letters, 1991, 32(33): 4169-4170.
