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Cat. No.: HY-118760

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Litebamine

Litebamine is a phenanthrene alkaloid with antiplatelet activity. Litebamine potently targets arachidonic acid- and collagen-induced platelet aggregation, but shows no activity against thrombin-induced aggregation. Litebamine inhibits arachidonic acid- and collagen-induced ATP release and thromboxane B₂ production in rabbit platelets, without altering cyclic AMP levels or phosphoinositide breakdown in rabbit platelets. Litebamine has no effect on platelet-activating factor- or U46619 (HY-108566)-induced aggregation, nor does it affect [³H] inositol monophosphate production in rabbit platelets induced by collagen, platelet-activating factor or thrombin.

For research use only. We do not sell to patients.

CAS No.: 137031-56-2
Formula: C₂₀H₂₁NO₄
Molecular Weight:339.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Litebamine Chemical Structure

CAS No.: 137031-56-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Prostaglandin Receptor Isoforms :

In Vitro

Litebamine (1.5-60 μM; 3 min) suppresses adrenaline- and ADP-induced secondary aggregation (but not primary aggregation) in human platelet-rich plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

human platelet-rich plasma
Concentration:

1.5-60 μM
Incubation Time:

3 min
Result:

Completely inhibited at 30 μM for adrenaline-induced secondary aggregation and 60 μM for ADP-induced secondary aggregation.

Chemical Information

CAS No. 137031-56-2
Molecular Weight 339.39
Formula C₂₀H₂₁NO₄
SMILES

OC(C=C1C=CC2=C(CCN(C3)C)C3=C4O)=C(OC)C=C1C2=C4OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Teng CM, et al. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. The Journal of pharmacy and pharmacology. 1997 Jul;49(7):706-11. [Content Brief]

[2]. Wu Y C, et al. Litebamine, a novel phenanthrene alkaloid from Litsea cubeba[J]. Tetrahedron letters, 1991, 32(33): 4169-4170.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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