138544-91-9
Chemical Structure
9-Hydroxycanthin-6-one
- CAS No.: 138544-91-9
- Formula:C14H8N2O2
- Molecular Weight:236.23
IUPAC Name: 9-hydroxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
InChIKey: JHPIJMUNSMWWAA-UHFFFAOYSA-N
SMILES: O=C1N2C3=C(N=CC=C3C4=C2C=C(O)C=C4)C=C1
Biological Activity: 9-Hydroxycanthin-6-one is a β-carboline alkaloid. 9-Hydroxycanthin-6-one can be isolated from the roots of E. longifolia. 9-Hydroxycanthin-6-one inhibits TNF-α-induced activation of the NF-κB pathway. 9-Hydroxycanthin-6-one activates GSK3β independently of CK1α, drives phosphorylation and degradation of β-catenin, and inhibits the Wnt signaling pathway. 9-Hydroxycanthin-6-one exerts selective cytotoxicity against Wnt-dependent colon cancer cells. 9-Hydroxycanthin-6-one can be used in studies related to colon cancer[1][2].
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9-Hydroxycanthin-6-one | 9-Hydroxycanthin-6-one is a β-carboline alkaloid. 9-Hydroxycanthin-6-one can be isolated from the roots of E. longifolia. 9-Hydroxycanthin-6-one inhibits TNF-α-induced activation of the NF-κB pathway. 9-Hydroxycanthin-6-one activates GSK3β independently of CK1α, drives phosphorylation and degradation of β-catenin, and inhibits the Wnt signaling pathway. 9-Hydroxycanthin-6-one exerts selective cytotoxicity against Wnt-dependent colon cancer cells. 9-Hydroxycanthin-6-one can be used in studies related to colon cancer. | |||||||||||||||||||||
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References
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[1]. Thi Van Anh Tran, et al. NF-κB inhibitors from Eurycoma longifolia. J Nat Prod. 2014 Mar 28;77(3):483-8.
[Content Brief] - [2]. Ohishi K, et al. 9-Hydroxycanthin-6-one, a β-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3β without Depending on Casein Kinase 1α. J Nat Prod. 2015 May 22;78(5):1139-46. [Content Brief]
