1398066-18-6
1398066-18-6
Chemical Structure
Mono-Cyclohexyl Phthalate-3,4,5,6-d4
- CAS No.: 1398066-18-6
- Formula:C14H12D4O4
- Molecular Weight:252.30
IUPAC Name: (S)-4-((5,7-difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide
InChIKey: PMDKYLLIOLFQPO-DOGSKSIHSA-N
SMILES: O=C(C1=C(C([2H])=C([2H])C([2H])=C1[2H])C(O)=O)OC2CCCCC2
Biological Activity: Mono-Cyclohexyl Phthalate-3,4,5,6-d4 is the d4-labeled Monocyclohexyl phthalate (HY-W701876). Monocyclohexyl phthalate is a phthalate metabolite and a competitive UGT1A9 inhibitor with an IC50 of 3.29 μM and a Ki of 0.09 μM. Monocyclohexyl phthalate can be used in research on impaired sperm quality and birth weight[1][2][3][4].
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Mono-Cyclohexyl Phthalate-3,4,5,6-d4 | 99.07% | Mono-Cyclohexyl Phthalate-3,4,5,6-d4 is the d4-labeled Monocyclohexyl phthalate (HY-W701876). Monocyclohexyl phthalate is a phthalate metabolite and a competitive UGT1A9 inhibitor with an IC50 of 3.29 μM and a Ki of 0.09 μM. Monocyclohexyl phthalate can be used in research on impaired sperm quality and birth weight. | ||||||||||||||||||||
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Monocyclohexyl phthalate | Monocyclohexyl phthalate is a phthalate metabolite and a competitive UGT1A9 inhibitor with an IC50 of 3.29 μM and a Ki of 0.09 μM. Monocyclohexyl phthalate can be used in research on impaired sperm quality and birth weight. | |||||||||||||||||||||
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References
- [1]. Du Z, et al. Inhibition of UDP-glucuronosyltransferases (UGTs) by phthalate monoesters. Chemosphere. 2018 Apr;197:7-13. [Content Brief]
- [2]. Vrachnis N, et al. Phthalates and fetal growth velocity: tracking down the suspected links. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2022 Dec;35(25):4985-4993.
- [3]. Duty SM, et al. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environmental health perspectives. 2003 Jul;111(9):1164-9.
- [4]. Duty SM, et al. Phthalate exposure and human semen parameters. Epidemiology (Cambridge, Mass.). 2003 May;14(3):269-77.
