1414805-62-1
1414805-62-1
Chemical Structure
JAK-IN-13
- CAS No.: 1414805-62-1
- Formula:C18H19N7O2
- Molecular Weight:365.39
IUPAC Name: 2-((1r,4r)-4-(8-oxo-2-((2-oxo-1,2-dihydropyridin-3-yl)amino)-7,8-dihydro-9H-purin-9-yl)cyclohexyl)acetonitrile
InChIKey: NIIBPFADTOPKBI-HAQNSBGRSA-N
SMILES: N#CC[C@@H]1CC[C@@H](N2C(NC3=CN=C(NC4=CC=CNC4=O)N=C23)=O)CC1
Biological Activity: JAK-IN-13 is a pan-JAK inhibitor. JAK-IN-13 inhibits JAK1, JAK2, JAK3, and Tyk2, with human IC50 values of 5.5 nM, 1.5 nM, 3.5 nM, and 130 nM, respectively. JAK-IN-13 inhibits neutrophilia and reduces IL-6 levels in an acute rat model of airway inflammation. JAK-IN-13 can be used for research on airway inflammation[1].
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JAK-IN-13 | JAK-IN-13 is a pan-JAK inhibitor. JAK-IN-13 inhibits JAK1, JAK2, JAK3, and Tyk2, with human IC50 values of 5.5 nM, 1.5 nM, 3.5 nM, and 130 nM, respectively. JAK-IN-13 inhibits neutrophilia and reduces IL-6 levels in an acute rat model of airway inflammation. JAK-IN-13 can be used for research on airway inflammation. | |||||||||||||||||||||
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