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Cat. No.: HY-126545

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JAK-IN-13

JAK-IN-13 is a pan-JAK inhibitor. JAK-IN-13 inhibits JAK1, JAK2, JAK3, and Tyk2, with human IC₅₀ values of 5.5 nM, 1.5 nM, 3.5 nM, and 130 nM, respectively. JAK-IN-13 inhibits neutrophilia and reduces IL-6 levels in an acute rat model of airway inflammation. JAK-IN-13 can be used for research on airway inflammation.

For research use only. We do not sell to patients.

CAS No.: 1414805-62-1
Formula: C₁₈H₁₉N₇O₂
Molecular Weight:365.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JAK-IN-13 Chemical Structure

CAS No.: 1414805-62-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

JAK1

5.5 nM (IC₅₀)

JAK2

1.5 nM (IC₅₀)

JAK3

3.5 nM (IC₅₀)

IL-6

Tyk2

130 nM (IC₅₀)

All JAK Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Ramos	IC50	41 nM	Inhibition of IL-4-induced STAT-6 phosphorylation in human Ramos cells. Inhibition of IL-4-induced STAT-6 phosphorylation in human Ramos cells.	31609613
Monocyte	IC50	219 nM	Inhibition of GM-CSF-stimulated STAT-5 phosphorylation in human PBMC-derived monocytes. Inhibition of GM-CSF-stimulated STAT-5 phosphorylation in human PBMC-derived monocytes.	31609613
CHO	IC50	100 μM	Cytotoxicity against Chinese hamster ovary (CHO) cells with IC50 > 100 μM. Cytotoxicity against Chinese hamster ovary (CHO) cells with IC50 > 100 μM.	31609613

In Vitro

Adaptive ImmunityOthers

Adaptive Immunity

JAK-IN-13 (Compound 34) inhibits IL-4-induced STAT-6 phosphorylation in human Ramos cells with IC₅₀ = 41 nM^[1].

Others

JAK-IN-13 inhibits GM-CSF-stimulated STAT-5 phosphorylation in human monocytes with IC₅₀ = 219 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	AUC_inf	C_max
Rat^[1]	30 mg/kg	p.o.	/	32 ng·h/mL	7 ng/mL
Rat^[1]	0.41 mg/kg	i.t.	16.3 h	/	/

In Vivo

Innate Immunity

JAK-IN-13 (0.1-3 mg/kg; intratracheal administration) inhibits neutrophil accumulation, reduces IL-6 levels, and alleviates disease progression in an acute rat model of airway inflammation induced by LPS (HY-D1056) inhalation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

rat^[1]
Dosage:

0.01, 0.1, 1, and 3 mg/kg
Administration:

aerosolized nanosuspension, using phosphate-buffered
saline containing 0.2% Tween 80 and 0.3% methylcellulose as
vehicle
Result:

Significantly reduced IL-6 levels in bronchoalveolar lavage fluid (62% reduction).
Inhibited neutrophilia, with the strongest inhibitory effect observed at a dose of 3 mg/kg (56% inhibition rate).

Related Protocols :

Chemical Information

CAS No. 1414805-62-1
Molecular Weight 365.39
Formula C₁₈H₁₉N₇O₂
SMILES

N#CC[C@@H]1CC[C@@H](N2C(NC3=CN=C(NC4=CC=CNC4=O)N=C23)=O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bach J, et al. Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases. J Med Chem. 2019 Oct 24;62(20):9045-9060.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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JAK-IN-13

All JAK Isoforms

All Interleukin Related Isoforms