1415018-97-1
Chemical Structure
FM 1-43FX
- CAS No.: 1415018-97-1
- Formula:C29H49Cl3N4
- Molecular Weight:560.09
IUPAC Name: (E)-1-(3-((3-aminopropyl)dimethylammonio)propyl)-4-(4-(dibutylamino)styryl)pyridin-1-ium chloride hydrochloride
InChIKey: KTUIRYVXUXEABI-UHFFFAOYSA-L
SMILES: NCCC[N+](C)(CCC[N+]1=CC=C(C=C1)/C=C/C2=CC=C(N(CCCC)CCCC)C=C2)C.[Cl-].Cl.[Cl-]
Biological Activity: FM 1-43FX is a fluorescent styryl membrane dye that stains lipids green. FM 1-43FX labels extracellular vesicle lipid membranes, exosomes/microvesicles, and various sensory neurons through an endocytosis/vesicle recycling-dependent mechanism, and can label NFH-, calbindin-, and TH-positive mechanoreceptor subtypes. FM 1-43FX acts as a membrane-permeable MET channel blocker, partially inhibiting PIEZO1 and PIEZO2 currents in a voltage-dependent manner, and is used to assess cochlear/zebrafish MET function and detect fungal EV lipid transfer. FM 1-43FX can be used for research on progressive hearing loss[7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FM 1-43FX | 99.64% | FM 1-43FX is a fluorescent styryl membrane dye that stains lipids green. FM 1-43FX labels extracellular vesicle lipid membranes, exosomes/microvesicles, and various sensory neurons through an endocytosis/vesicle recycling-dependent mechanism, and can label NFH-, calbindin-, and TH-positive mechanoreceptor subtypes. FM 1-43FX acts as a membrane-permeable MET channel blocker, partially inhibiting PIEZO1 and PIEZO2 currents in a voltage-dependent manner, and is used to assess cochlear/zebrafish MET function and detect fungal EV lipid transfer. FM 1-43FX can be used for research on progressive hearing loss. | ||||||||||||||||||||
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