142878-03-3
Chemical Structure
Toddacoumaquinone
- CAS No.: 142878-03-3
- Formula:C23H18O7
- Molecular Weight:406.39
IUPAC Name: 8-(5,7-dimethoxy-2-oxo-2H-chromen-8-yl)-2-methoxy-6-methylnaphthalene-1,4-dione
InChIKey: SQTLGMZYHSFVGI-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C=C1)C(OC)=CC(OC)=C2C3=CC(=CC=4C(=O)C=C(OC)C(=O)C43)C
Biological Activity: Toddacoumaquinone is a coumarin-naphthoquinone dimer found in the roots of Toddalia asiatica. Toddacoumaquinone inhibits acetylcholinesterase (AChE) and β-amyloid (Aβ1-42) aggregation, with an IC50 of 46 μM against electric eel acetylcholinesterase. Toddacoumaquinone exerts antiviral effects against herpes simplex virus type 1 and herpes simplex virus type 2 (HSV). Toddacoumaquinone is used in research related to Alzheimer's disease and herpesvirus infections[1][2].
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Toddacoumaquinone | Toddacoumaquinone is a coumarin-naphthoquinone dimer found in the roots of Toddalia asiatica. Toddacoumaquinone inhibits acetylcholinesterase (AChE) and β-amyloid (Aβ1-42) aggregation, with an IC50 of 46 μM against electric eel acetylcholinesterase. Toddacoumaquinone exerts antiviral effects against herpes simplex virus type 1 and herpes simplex virus type 2 (HSV). Toddacoumaquinone is used in research related to Alzheimer's disease and herpesvirus infections. | |||||||||||||||||||||
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References
- [1]. Takomthong P, et al. Structure-Activity Analysis and Molecular Docking Studies of Coumarins from Toddalia asiatica as Multifunctional Agents for Alzheimer's Disease. Biomedicines. 2020 May 2;8(5):107. [Content Brief]
- [2]. Ishikawa T, et al. Synthesis of toddacoumaquinone, a coumarin-naphthoquinone dimer, and its antiviral activities. Chemical & pharmaceutical bulletin. 1995 Jun;43(6):1039-41. [Content Brief]
