148274-82-2
Chemical Structure
OVA G4 peptide
- CAS No.: 148274-82-2
- Formula:C43H71N9O12
- Molecular Weight:906.08
IUPAC Name: (2S,5S,8S,11S,17S,20S,23S)-23-amino-5-(4-aminobutyl)-11-benzyl-17,20-di((S)-sec-butyl)-8-(2-carboxyethyl)-24-hydroxy-2-isobutyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanoic acid
InChIKey: OFRBIWSONSKXDO-PZELKCDDSA-N
SMILES: CC(C)C[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CC1=CC=CC=C1)NC(CNC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CO)N)=O)=O)=O)=O)=O)=O)=O
Biological Activity: OVA G4 peptide is a modified peptide ligand derived from ovalbumin and also a weak OT-I TCR agonist. OVA G4 peptide binds OT-I TCR with a certain affinity, stimulates TCR signaling, and induces T cell activation. OVA G4 peptide can be used in research related to OVA-expressing tumors[1][2][3].
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OVA G4 peptide | OVA G4 peptide is a modified peptide ligand derived from ovalbumin and also a weak OT-I TCR agonist. OVA G4 peptide binds OT-I TCR with a certain affinity, stimulates TCR signaling, and induces T cell activation. OVA G4 peptide can be used in research related to OVA-expressing tumors. | |||||||||||||||||||||
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References
- [1]. Mandarano AH, et al. DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development. Cell reports. 2023 Feb 28;42(2):112106.
- [2]. Cheng B, et al. Targeting MDA5 enhances tumor immunity through immunogenic cell death and augments the efficacy of immune checkpoint blockade.
- [3]. Ferran H, et al. The MARK2 kinase acts as a gatekeeper of CD28-dependent co-stimulation in T cells. bioRxiv. 2025 Oct 14:2025-10.
