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Cat. No.: HY-P1771

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OVA G4 peptide

OVA G4 peptide is a modified peptide ligand derived from ovalbumin and also a weak OT-I TCR agonist. OVA G4 peptide binds OT-I TCR with a certain affinity, stimulates TCR signaling, and induces T cell activation. OVA G4 peptide can be used in research related to OVA-expressing tumors.

For research use only. We do not sell to patients.

CAS No.: 148274-82-2
Formula: C₄₃H₇₁N₉O₁₂
Molecular Weight:906.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

OVA G4 peptide Chemical Structure

CAS No.: 148274-82-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All MHC Isoforms :

MHC I
MHC II

In Vitro

Adaptive ImmunityInnate Immunity

Adaptive Immunity

OVA G4 peptide stimulates Drak2-knockout OT-I CD8⁺ T cells, where cell proliferation is stronger than in wild-type cells, but Nur77-GFP signaling is instead lower, demonstrating that the enhanced T cell proliferation mediated by Drak2 deficiency does not depend on increased TCR signaling strength^[1].
OVA G4 peptide stimulation induces CD69 and CD25 upregulation in WT and MARK2-deficient OT-I naive CD8⁺ T cells^[3].

Innate Immunity

Adaptive Immunity

OVA G4 peptide can be used as a model antigen in antigen restimulation experiments; in MDA5-targeted in vivo antitumor models, OVA G4 peptide restimulation detects enhanced tumor-specific memory T cell responses^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cancer Immunology

Chemical Information

CAS No. 148274-82-2
Molecular Weight 906.08
Formula C₄₃H₇₁N₉O₁₂
Sequence

Ser-Ile-Ile-Gly-Phe-Glu-Lys-Leu
Sequence Shortening

SIIGFEKL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mandarano AH, et al. DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development. Cell reports. 2023 Feb 28;42(2):112106.

[2]. Cheng B, et al. Targeting MDA5 enhances tumor immunity through immunogenic cell death and augments the efficacy of immune checkpoint blockade.

[3]. Ferran H, et al. The MARK2 kinase acts as a gatekeeper of CD28-dependent co-stimulation in T cells. bioRxiv. 2025 Oct 14:2025-10.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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