153312-20-0
Chemical Structure
Tgg-II-23A
- CAS No.: 153312-20-0
- Formula:C17H19NO2
- Molecular Weight:269.34
IUPAC Name: 1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1,4-dimethylnaphthalen-2(1H)-one
InChIKey: QRWXKCZIDVOJIQ-UHFFFAOYSA-N
SMILES: O=C1C=C(C=2C=CC=CC2C1(C3=NC(C)(C)CO3)C)C
Biological Activity: Tgg-II-23A is a non-nucleoside HIV-1 reverse transcriptase inhibitor, with an IC50 of 136 μM against HIV-1 NL4-3 reverse transcriptase. Tgg-II-23A exhibits antiviral activity against wild-type HIV-1, but shows reduced activity against TIBO R82150 (HY-19111)-resistant HIV-1 strains carrying reverse transcriptase mutations. Tgg-II-23A does not inhibit the replication of HIV-2. Tgg-II-23A can be used in studies related to HIV-1 infection[1][2].
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Tgg-II-23A | Tgg-II-23A is a non-nucleoside HIV-1 reverse transcriptase inhibitor, with an IC50 of 136 μM against HIV-1 NL4-3 reverse transcriptase. Tgg-II-23A exhibits antiviral activity against wild-type HIV-1, but shows reduced activity against TIBO R82150 (HY-19111)-resistant HIV-1 strains carrying reverse transcriptase mutations. Tgg-II-23A does not inhibit the replication of HIV-2. Tgg-II-23A can be used in studies related to HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Alam M, et al. Substituted naphthalenones as a new structural class of HIV-1 reverse transcriptase inhibitors. Antiviral research. 1993 Oct;22(2-3):131-41.
- [2]. Samanta H, et al. Characterization of a Mutant HIV-1 Reverse Transcriptase Resistant to (+)-(5S)-4, 5, 6, 7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)-imidazo [4, 5, 1-jk][1, 4] benzodiazepin-2 (1 H)-thione (TIBO R82150)[J]. Antiviral Chemistry and Chemotherapy, 1994, 5(4): 278-281.
