153569-12-1
Chemical Structure
SPDP-sulfo sodium
- CAS No.: 153569-12-1
- Formula:C12H11N2NaO7S3
- Molecular Weight:414.41
InChIKey: IGUCKQRSISNDCP-UHFFFAOYSA-M
SMILES: O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCSSC2=NC=CC=C2
Biological Activity: SPDP-sulfo sodium is a water-soluble heterobifunctional crosslinker containing a cleavable disulfide bond. SPDP-sulfo sodium forms a stable amide bond with primary amines through the Sulfo-NHS ester at one end, and reacts with sulfhydryl groups via the 2-pyridyldithiol group at the other end, thereby constructing a disulfide crosslink that can be specifically cleaved in the intracellular reducing microenvironment. SPDP-sulfo sodium can be widely used in the research and construction of ADCs and immunotoxins, receptor-mediated nano-targeted carrier delivery systems, and enzyme-antibody/antigen labels[1][2][3][4].
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SPDP-sulfo sodium | SPDP-sulfo sodium is a water-soluble heterobifunctional crosslinker containing a cleavable disulfide bond. SPDP-sulfo sodium forms a stable amide bond with primary amines through the Sulfo-NHS ester at one end, and reacts with sulfhydryl groups via the 2-pyridyldithiol group at the other end, thereby constructing a disulfide crosslink that can be specifically cleaved in the intracellular reducing microenvironment. SPDP-sulfo sodium can be widely used in the research and construction of ADCs and immunotoxins, receptor-mediated nano-targeted carrier delivery systems, and enzyme-antibody/antigen labels. | |||||||||||||||||||||
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References
- [1]. Carlsson J, et al. Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent. Biochem J. 1978;173(3):723-737.
- [2]. Shukla R, et al. HER2 specific tumor targeting with dendrimer conjugated anti-HER2 mAb. Bioconjugate chemistry. 2006;17(5):1109-15.
- [3]. Ghetie V, et al. Chemical construction of immunotoxins. Molecular biotechnology. 2001 Jul;18(3):251-68.
