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Cat. No.: HY-133543A

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SPDP-sulfo sodium

Name: SPDP-sulfo sodium
Brand: MedChemExpress
SKU: HY-133543A
Price: 75.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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SPDP-sulfo sodium is a water-soluble heterobifunctional crosslinker containing a cleavable disulfide bond. SPDP-sulfo sodium forms a stable amide bond with primary amines through the Sulfo-NHS ester at one end, and reacts with sulfhydryl groups via the 2-pyridyldithiol group at the other end, thereby constructing a disulfide crosslink that can be specifically cleaved in the intracellular reducing microenvironment. SPDP-sulfo sodium can be widely used in the research and construction of ADCs and immunotoxins, receptor-mediated nano-targeted carrier delivery systems, and enzyme-antibody/antigen labels.

For research use only. We do not sell to patients.

CAS No.: 153569-12-1
Formula: C₁₂H₁₁N₂NaO₇S₃
Molecular Weight:414.41

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SPDP-sulfo sodium Chemical Structure

CAS No.: 153569-12-1

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Top Publications Citing

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 153569-12-1
Appearance Solid
Molecular Weight 414.41
Formula C₁₂H₁₁N₂NaO₇S₃
SMILES

O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCSSC2=NC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Carlsson J, et al. Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent. Biochem J. 1978;173(3):723-737.

[2]. Shukla R, et al. HER2 specific tumor targeting with dendrimer conjugated anti-HER2 mAb. Bioconjugate chemistry. 2006;17(5):1109-15.

[3]. Ghetie V, et al. Chemical construction of immunotoxins. Molecular biotechnology. 2001 Jul;18(3):251-68.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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