158584-09-9
Chemical Structure
NFF-3
- CAS No.: 158584-09-9
- Formula:C78H110N22O20
- Molecular Weight:1675.84
IUPAC Name: (S)-5-(((S)-1-(((S)-1-(((S)-1-(((S)-1-amino-6-((2,4-dinitrophenyl)amino)-1-oxohexan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)amino)-4-((S)-2-((S)-1-((2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl)-L-arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-3-methylbutanamido)-5-oxopentanoic acid
InChIKey: TVZDWYYXHAIMCR-BKNSPTOHSA-N
SMILES: O=[N+]([O-])C(C=C(C=C1)[N+]([O-])=O)=C1NCCCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@H]2N(CCC2)C([C@H](CCCCN)NC([C@H]3N(CCC3)C([C@H](CCCNC(N)=N)NC(CC(C4=CC=C(OC)C=C4O5)=CC5=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O
Biological Activity: NFF-3 is a MMP-3-selective fluorescent peptide substrate that is efficiently hydrolyzed by MMP-3. NFF-3 can be used in research related to MMP-3 enzyme activity detection[1][2][3].
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NFF-3 | NFF-3 is a MMP-3-selective fluorescent peptide substrate that is efficiently hydrolyzed by MMP-3. NFF-3 can be used in research related to MMP-3 enzyme activity detection. | |||||||||||||||||||||
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References
- [1]. Cheng L, et al. Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections. Acta pharmaceutica Sinica. B. 2021 Oct;11(10):3220-3230.
- [2]. Nagase H, et al. Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). The Journal of biological chemistry. 1994 Aug 19;269(33):20952-7.
- [3]. Cheng D, et al. High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy. Bioactive materials. 2024 May;35:517-533.