159187-70-9
159187-70-9
Chemical Structure
MM 77 dihydrochloride
- CAS No.: 159187-70-9
- Formula:C19H29Cl2N3O3
- Molecular Weight:418.36
IUPAC Name: 1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyrrolidine-2,5-dione dihydrochloride
InChIKey: ZYCVVOZXHNDRCO-UHFFFAOYSA-N
SMILES: O=C(CC1)N(CCCCN2CCN(C3=CC=CC=C3OC)CC2)C1=O.Cl.Cl
Biological Activity: MM 77 dihydrochloride is a potent and selective 5-HT1A receptor antagonist with a Ki of 6.4 nM. MM 77 dihydrochloride competitively binds to the 5-HT1A receptor and blocks downstream G protein activation. MM 77 dihydrochloride can be used for research on depression[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MM 77 dihydrochloride | 99.88% | MM 77 dihydrochloride is a potent and selective 5-HT1A receptor antagonist with a Ki of 6.4 nM. MM 77 dihydrochloride competitively binds to the 5-HT1A receptor and blocks downstream G protein activation. MM 77 dihydrochloride can be used for research on depression. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Tinh NT, et al. Interference with the quorum sensing systems in a Vibrio harveyi strain alters the growth rate of gnotobiotically cultured rotifer Brachionus plicatilis. Journal of applied microbiology. 2007 Jul;103(1):194-203.
- [2]. Odagaki Y, et al. Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. Journal of psychopharmacology (Oxford, England). 2016 Sep;30(9):896-912. [Content Brief]
- [3]. Egashira N, et al. Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system. European journal of pharmacology. 2008 Jul 28;589(1-3):117-21.
- [4]. Zavitsanou K, et al. Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats. Neuroscience. 2010 Aug 11;169(1):315-24.
- [5]. Bojarski AJ, et al. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics. Bioorganic & medicinal chemistry. 2005 Mar 15;13(6):2293-303.
- [6]. Barnes NM, et al. Neuronal 5-HT receptors and SERT. Tocris Biosci Sci Rev Ser. 2011;34:1-6.
- [7]. Dalton VS, et al. Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus: Testing the "Two Hit" Hypothesis for the Development of Schizophrenia. ISRN psychiatry. 2012;2012:451865.
