MM 77 dihydrochloride
Based on 1 Customer Validation
MM 77 dihydrochloride is a potent and selective 5-HT1A receptor antagonist with a Ki of 6.4 nM. MM 77 dihydrochloride competitively binds to the 5-HT1A receptor and blocks downstream G protein activation. MM 77 dihydrochloride can be used for research on depression.
For research use only. We do not sell to patients.
- Purity : 99.88%
- CAS No.: 159187-70-9
- Formula: C19H29Cl2N3O3
- Molecular Weight:418.36
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
5-HT1A Receptor 6.4 nM (Ki) |
5-HT2A Receptor 1510 nM (Ki) |
Human 5-HT7 Receptor 90 nM (Ki) |
In Vitro
MM77 (30-120 min) dihydrochloride exhibits binding activity to 5-HT1A, 5-HT2A, 5-HT7, α1, and D2 receptors in rat brain cell membranes (hippocampus, cerebral cortex, hypothalamus, striatum), with Ki values of 6.4, 1510, 90, and 490 nM[5].
MM 77 dihydrochloride (10 μM; 60 min) blocks nonspecific binding of 5-HT1A receptors in rat brain tissue sections[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MM77 (4-8 mg/kg; i.p.; single administration; tested 15-45 min after injection) dihydrochloride antagonizes 8-OH-DPAT-induced lower lip retraction (LLR) behavior in Wistar rats[5].
MM77 (4-8 mg/kg; i.p.; single administration; tested 3-15 min after injection) antagonizes 8-OH-DPAT-induced flat body posture and forepaw treading in the reserpine (HY-N0480)-treated Wistar rat model[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ddY (male, 6 weeks old, 25-30 g)[3]
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Dosage:0.1 mg/kg
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Administration:i.p.; single administration; 30 min before test session
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Result:Reversed the reduction effect of the 5-HT1A agonist (8-OH-DPAT) on THC-induced prolongation of immobility time.
Chemical Information
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CAS No. 159187-70-9
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Appearance Solid
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Molecular Weight 418.36
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Formula C19H29Cl2N3O3
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Color White to off-white
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SMILES
O=C(CC1)N(CCCCN2CCN(C3=CC=CC=C3OC)CC2)C1=O.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (119.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[2]. Odagaki Y, et al. Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. Journal of psychopharmacology (Oxford, England). 2016 Sep;30(9):896-912. [Content Brief]
[6]. Barnes NM, et al. Neuronal 5-HT receptors and SERT. Tocris Biosci Sci Rev Ser. 2011;34:1-6.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3903 mL | 11.9514 mL | 23.9029 mL | 59.7571 mL |
| 5 mM | 0.4781 mL | 2.3903 mL | 4.7806 mL | 11.9514 mL | |
| 10 mM | 0.2390 mL | 1.1951 mL | 2.3903 mL | 5.9757 mL | |
| 15 mM | 0.1594 mL | 0.7968 mL | 1.5935 mL | 3.9838 mL | |
| 20 mM | 0.1195 mL | 0.5976 mL | 1.1951 mL | 2.9879 mL | |
| 25 mM | 0.0956 mL | 0.4781 mL | 0.9561 mL | 2.3903 mL | |
| 30 mM | 0.0797 mL | 0.3984 mL | 0.7968 mL | 1.9919 mL | |
| 40 mM | 0.0598 mL | 0.2988 mL | 0.5976 mL | 1.4939 mL | |
| 50 mM | 0.0478 mL | 0.2390 mL | 0.4781 mL | 1.1951 mL | |
| 60 mM | 0.0398 mL | 0.1992 mL | 0.3984 mL | 0.9960 mL | |
| 80 mM | 0.0299 mL | 0.1494 mL | 0.2988 mL | 0.7470 mL | |
| 100 mM | 0.0239 mL | 0.1195 mL | 0.2390 mL | 0.5976 mL |
MM 77 dihydrochloride Related Classifications
HY-101322A Related Classifications
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