161442-19-9
Chemical Structure
2'-F-Bz-dC Phosphoramidite
- CAS No.: 161442-19-9
- Formula:C46H51FN5O8P
- Molecular Weight:851.90
IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChIKey: CKKJPMGSTGVCJJ-GNUWXFRUSA-N
SMILES: COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N4C=CC(NC(C5=CC=CC=C5)=O)=NC4=O)O3)C6=CC=CC=C6)C=C1
Biological Activity: 2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2'-F-Bz-dC Phosphoramidite | 99.48% | 2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells. | ||||||||||||||||||||
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References
- [1]. Reif B, et, al. Structural Comparison of Oligoribonucleotides and Their 2′-Deoxy-2′-fluoro Analogs by heteronuclear NMR spectroscopy. Helvetica Chimica Acta. 1997 Jou; 80(6): 1952-1971.
- [2]. Zhang Hongyan, et al. Combined drug for treating hepatitis B and its application in preparing drugs for preventing and/or treating HBV (hepatitis B virus)-induced symptom or diseases. China, CN112007040 A. 2020-12-01.
- [3]. Monia Brett P, et al. Antisense oligonucleotides for modulation of telomerase catalytic subunit gene expression and treatment of cancer. World Intellectual Property Organization, WO2001088198 A1. 2001-11-22.
