1624617-93-1
Chemical Structure
Pronaphthalide A
- CAS No.: 1624617-93-1
- Formula:C22H20O7
- Molecular Weight:396.40
IUPAC Name: 9-(3-hydroxy-4-methoxyphenyl)-4,6,7-trimethoxynaphtho[2,3-c]furan-1(3H)-one
InChIKey: QXFKCOKSRLHYRN-UHFFFAOYSA-N
SMILES: O=C1OCC=2C(OC)=C3C=C(OC)C(OC)=CC3=C(C=4C=CC(OC)=C(O)C4)C12
Biological Activity: Pronaphthalide A is a cytotoxic agent and an inhibitor of SFTSV glycoprotein Gn (domain B) (Kd = 0.74 mM). It blocks viral binding and internalization by binding to the conserved B domain of SFTSV Gn, thereby inhibiting SFTSV infection at the viral entry stage, and exhibits broad-spectrum antiviral activity against bunyaviruses. Pronaphthalide A can be used for research on gastric cancer, severe fever with thrombocytopenia syndrome, and HIV/AIDS[1][2][3].
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Pronaphthalide A | Pronaphthalide A is a cytotoxic agent and an inhibitor of SFTSV glycoprotein Gn (domain B) (Kd = 0.74 mM). It blocks viral binding and internalization by binding to the conserved B domain of SFTSV Gn, thereby inhibiting SFTSV infection at the viral entry stage, and exhibits broad-spectrum antiviral activity against bunyaviruses. Pronaphthalide A can be used for research on gastric cancer, severe fever with thrombocytopenia syndrome, and HIV/AIDS. | |||||||||||||||||||||
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References
- [1]. Jin H, et al. Cytotoxic activity of lignans from Justicia procumbens. Fitoterapia. 2014 Apr 1;94:70-6.
- [2]. Carneiro MRB, et al. Overview of the Genus: Insights into Its Chemical Diversity and Biological Potential. Molecules (Basel, Switzerland). 2023 Jan 25;28(3):1190.
- [3]. Huang J, et al. Effectiveness of lignans against severe fever with thrombocytopenia syndrome virus infection. Virologica Sinica. 2026 Aug;41(4):912-922.
