1626387-96-9
1626387-96-9
Chemical Structure
EGFR ligand-21
- CAS No.: 1626387-96-9
- Formula:C21H21ClFN5O3
- Molecular Weight:445.87
InChIKey: DTTLIAUCEWLOSF-GFCCVEGCSA-N
SMILES: COC(C(OC(N1[C@@H](CNCC1)C)=O)=C2)=CC3=C2C(NC4=C(C(Cl)=CC=C4)F)=NC=N3
Biological Activity: EGFR ligand-21 is the N-desmethyl precursor of Zorifertinib (HY-18750) and can also serve as an EGFR ligand for PROTAC synthesis[1][2].
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EGFR ligand-21 | EGFR ligand-21 is the N-desmethyl precursor of Zorifertinib (HY-18750) and can also serve as an EGFR ligand for PROTAC synthesis. | |||||||||||||||||||||
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References
- [1]. Hua Y N, et al. Preparation method of zolitinib hydrochloride raw material. CN117417326A. China. 2024 01 19.
- [2]. Xiang Ni, et al. Discovery of Potent and Selective VHL-Recruiting PROTAC Degraders Targeting EGFR with Improved Developability and Potent Anti-NSCLC Efficacy. J. Med. Chem. 8 October 2026; 69 (19): 22671-22698.
