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Cat. No.: HY-189916

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EGFR ligand-21

EGFR ligand-21 is the N-desmethyl precursor of Zorifertinib (HY-18750) and can also serve as an EGFR ligand for PROTAC synthesis.

For research use only. We do not sell to patients.

CAS No.: 1626387-96-9
Formula: C₂₁H₂₁ClFN₅O₃
Molecular Weight:445.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR ligand-21 Chemical Structure

CAS No.: 1626387-96-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

EGFR ligand-21 is the N-desmethyl precursor of Zorifertinib (HY-18750) and can also serve as an EGFR ligand for PROTAC synthesis^[1]^[2].

IC₅₀ & Target

EGFR^del19

EGFR^L858R

In Vitro

EGFR ligand-21 (compound 8) is obtained by Boc-deprotection of compound 7, followed by reductive amination with formaldehyde and sodium triacetoxyborohydride to achieve N-methylation, yielding Zorifertinib^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1626387-96-9
Molecular Weight 445.87
Formula C₂₁H₂₁ClFN₅O₃
SMILES

COC(C(OC(N1[C@@H](CNCC1)C)=O)=C2)=CC3=C2C(NC4=C(C(Cl)=CC=C4)F)=NC=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hua Y N, et al. Preparation method of zolitinib hydrochloride raw material. CN117417326A. China. 2024 01 19.

[2]. Xiang Ni, et al. Discovery of Potent and Selective VHL-Recruiting PROTAC Degraders Targeting EGFR with Improved Developability and Potent Anti-NSCLC Efficacy. J. Med. Chem. 8 October 2026; 69 (19): 22671-22698.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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