1638973-78-0
1638973-78-0
Chemical Structure
MitoEbselen-2 chloride
Synonym(s): MitoPeroxidase 2
- CAS No.: 1638973-78-0
- Formula:C35H30ClN2O2PSe
- Molecular Weight:656.01
IUPAC Name: (2-(2-(4-(3-oxobenzo[d][1,2]selenazol-2(3H)-yl)phenyl)acetamido)ethyl)triphenylphosphonium chloride
InChIKey: RWZPPTYDYPSPOY-UHFFFAOYSA-N
SMILES: O=C(NCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=C(N5[Se]C6=C(C=CC=C6)C5=O)C=C4.[Cl-]
Biological Activity: MitoEbselen-2 chloride (MitoPeroxidase 2), a mitochondria-targeted mimic of glutathione peroxidase, is a radiation mitigator. MitoEbselen-2 chloride is effective in reducing lipid hydroperoxides, preventing apoptotic cell death[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MitoEbselen-2 chloride | 95.62% | MitoEbselen-2 chloride (MitoPeroxidase 2), a mitochondria-targeted mimic of glutathione peroxidase, is a radiation mitigator. MitoEbselen-2 chloride is effective in reducing lipid hydroperoxides, preventing apoptotic cell death. | ||||||||||||||||||||
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MitoBADY | 98% | MitoBADY is a mitochondria-selective Raman probe that successfully visualizes mitochondria in live HeLa cells at a concentration of 200-400 nM for 10 minutes. MitoBADY can be utilized for the study of mitochondrial dynamics. | ||||||||||||||||||||
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MitoPQ | 99.14% | MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study. | ||||||||||||||||||||
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Mito-apocynin (C2) | 98.41% | Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect. | ||||||||||||||||||||
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FBA-IN-1 | 99.92% | FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL. | ||||||||||||||||||||
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Antifungal agent 47 | Antifungal agent 47 (compound 3b) shows the highest and broad-spectrum fungicidal activity, strong respiratory inhibition activity, and adenosine 5′-triphosphate synthesis inhibition activity. Antifungal agent 47 is potential as a fungicide. | |||||||||||||||||||||
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TrxR1-IN-1 | TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC50: 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC50s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical. | |||||||||||||||||||||
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Mito-Esculetin | Mito-Esculetin (Mito-Esc) is an orally active mitochondria-targeted derivative of Esculetin (HY-N0284). Mito-Esculetin inhibits LPS-induced phosphorylation of STAT3 Tyr-705, partially reverses LPS-mediated depletion of SIRT3, and enhances the AMPK-SIRT1 signaling axis. Mito-Esculetin inhibits PAI-1 activity, regulates miRNA, and induces phosphorylation of IRS and AKT. Mito-Esculetin suppresses oxidant-induced endothelial dysfunction, Ang-II (HY-13948)- and high glucose-induced atherosclerotic plaque formation, Palmitate (HY-N0830)-induced insulin resistance, as well as high glucose-mediated endothelial cell senescence and inflammatory responses. Mito-Esculetin reduces body weight and non-esterified fatty acid (NEFA) levels. Mito-Esculetin can be used in research related to acute coronary syndrome, type 2 diabetes, and hyperglycemia-induced atherosclerosis. | |||||||||||||||||||||
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Magnolol-C4-TPP bromide | Magnolol-C4-TPP bromide is a mitochondria-targeted magnolol derivative with cytotoxic activity against cancer cells. Magnolol-C4-TPP bromide increases ROS levels and slightly reduces mitochondrial membrane potential in colon cancer cells. Magnolol-C4-TPP bromide can be used in the research of colorectal cancer, liver cancer, and breast cancer. | |||||||||||||||||||||
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WYneN | 99.0% | WYneN (compound 10) is a functionalized Wittig-alkyne probe. WYneN exhibits strong reactivity with sulfinic acid dipeptide models, similar to the parent Wittig reagent. WYneN can be used to reveal the function of oxidative modifications on a proteome-wide scale. | ||||||||||||||||||||
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Mito-laurdan bromide | 99% | Mito-laurdan (bromide) is a Fluorescent dye for mitochondrial membrane fluidity and packing measurement. It depends on membrane potential for targeting: it contains a cationic triphenylphosphonium moiety that accumulates at the inner mitochondrial membrane due to the membrane's negative potential, connected via a 3-carbon linker. As a solvatochromic dye derived from Laurdan (HY-D0080), it retains the characteristic mechanism where fluorescence emission shifts based on membrane packing: in more fluid, loosely packed membranes, greater water penetration leads to increased dipolar relaxation and a bathochromic red shift in emission, while more ordered membranes show a blue-shifted emission; these shifts are quantified using generalized polarization, calculated from emission intensities in ordered and disordered spectral windows. Its excitation wavelength is 352 nm, with emission detected in ordered (409-463 nm) and disordered (473-516 nm) spectral windows. It localizes specifically to mitochondria in HeLa cells, showing high signal overlap with MitoTracker Deep Red, and can detect changes in inner mitochondrial membrane fluidity. | ||||||||||||||||||||
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