1654761-54-2
Chemical Structure
PI-16
- CAS No.: 1654761-54-2
- Formula:C40H48N4O8
- Molecular Weight:712.84
IUPAC Name: 3,3',3'',3'''-((6E,9Z,16E,19Z)-3,5,5,7,13,15,15,17-octamethyl-5H,15H-porphyrin-2,8,12,18-tetrayl)tetrapropionic acid
InChIKey: RAYWFLVKWNBRGG-SZVCAHDZSA-N
SMILES: O=C(O)CCC=1C=2N=C(C1C)C(C=3NC(C=C4N=C(C(=C4CCC(=O)O)C)C(C=5NC(C2)=C(C5C)CCC(=O)O)(C)C)=C(C3C)CCC(=O)O)(C)C
Biological Activity: PI-16 is a selective uroporphyrinogen decarboxylase (UROD) inhibitor with an IC50 of 9.9 µM against human UROD. PI-16 inhibits the heme biosynthesis enzyme that converts uroporphyrinogen to coproporphyrinogen. PI-16 selectively reduces the viability of hypopharyngeal squamous cell carcinoma and cervical cancer cells. PI-16 can be used in combination with Cisplatin (HY-17394), with synergistic effects observed in hypopharyngeal squamous cell carcinoma cells. PI-16 can be used in research related to hypopharyngeal squamous cell carcinoma and cervical cancer[1].
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PI-16 | PI-16 is a selective uroporphyrinogen decarboxylase (UROD) inhibitor with an IC50 of 9.9 µM against human UROD. PI-16 inhibits the heme biosynthesis enzyme that converts uroporphyrinogen to coproporphyrinogen. PI-16 selectively reduces the viability of hypopharyngeal squamous cell carcinoma and cervical cancer cells. PI-16 can be used in combination with Cisplatin (HY-17394), with synergistic effects observed in hypopharyngeal squamous cell carcinoma cells. PI-16 can be used in research related to hypopharyngeal squamous cell carcinoma and cervical cancer. | |||||||||||||||||||||
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