168831-77-4
Chemical Structure
Protegrin-1
Synonym(s): PG1
- CAS No.: 168831-77-4
- Formula:C88H147N37O19S4
- Molecular Weight:2155.61
IUPAC Name: (1R,4S,7R,12R,15S,18R,21S,24S,27S,30S)-N-((S)-1-((2-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-3-methyl-1-oxobutan-2-yl)-21-benzyl-7-((6S,15S,18S)-1,6-diamino-15-(3-guanidinopropyl)-1-imino-18-isobutyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecan-19-amido)-24,27,30-tris(3-guanidinopropyl)-4-(4-hydroxybenzyl)-15-isopropyl-3,6,14,17,20,23,26,29,32-nonaoxo-9,10,34,35-tetrathia-2,5,13,16,19,22,25,28,31-nonaazabicyclo[16.14.4]hexatriacontane-12-carboxamide
InChIKey: FRUSITGRABAQQC-UEDJBKKJSA-N
SMILES: O=C(N[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N2)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(CNC(CNC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)C(C)C)=O)([H])CSSC1)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)[C@@H]2CC4=CC=C(C=C4)O
Biological Activity: Protegrin-1 is an orally active antibacterial peptide. Protegrin-1 activates ERK, COX2, NFκB, inhibits Apoptosis, and NO production. Protegrin-1 has antibacterial activity against S. aureus, E. faecium, E. coli, P. aeruginosa and K. Pneumoniae, with MBC values between 10 and 20 µM. Protegrin-1 has antiviral activity against dengue NS2B-NS3. Protegrin-1 has anti-inflammatory activity. Protegrin-1 is used in the study of inflammatory diseases and infections[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Protegrin-1 | 99.96% | Protegrin-1 is an orally active antibacterial peptide. Protegrin-1 activates ERK, COX2, NFκB, inhibits Apoptosis, and NO production. Protegrin-1 has antibacterial activity against S. aureus, E. faecium, E. coli, P. aeruginosa and K. Pneumoniae, with MBC values between 10 and 20 µM. Protegrin-1 has antiviral activity against dengue NS2B-NS3. Protegrin-1 has anti-inflammatory activity. Protegrin-1 is used in the study of inflammatory diseases and infections. | ||||||||||||||||||||
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References
- [1]. Rothan HA, et al. Protegrin-1 inhibits dengue NS2B-NS3 serine protease and viral replication in MK2 cells. J Biomed Biotechnol. 2012;2012:251482. [Content Brief]
- [2]. Penney J, et al. Protegrin 1 Enhances Innate Cellular Defense via the Insulin-Like Growth Factor 1 Receptor Pathway. Front Cell Infect Microbiol. 2018 Sep 28;8:331. [Content Brief]
- [3]. Soundrarajan N, et al. Protegrin-1 cytotoxicity towards mammalian cells positively correlates with the magnitude of conformational changes of the unfolded form upon cell interaction. Sci Rep. 2019 Aug 9;9(1):11569. [Content Brief]
- [4]. Tu Y, et al. Effect of astragalus and astragalus polysaccharide on antimicrobial peptides PR-39 and protegrin-1 gene expression in pigs. Turkish Journal of Veterinary & Animal Sciences, 2006, 30(3): 325-330.
- [5]. Li X, et al. Protegrin-1 inhibits porcine ovarian granulosa cell apoptosis from H2O2-induced oxidative stress via the PERK/eIF2α/CHOP signaling pathway in vitro. Theriogenology. 2022 Feb;179:117-127. [Content Brief]
- [6]. Javed A, et al. Antimicrobial and immunomodulatory activities of porcine cathelicidin Protegrin-1. Mol Immunol. 2024 Sep;173:100-109. [Content Brief]
- [7]. Steinberg DA, et al. Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity. Antimicrob Agents Chemother. 1997 Aug;41(8):1738-42. [Content Brief]
- [8]. Osakowicz C, et al. Protective and Anti-Inflammatory Effects of Protegrin-1 on Citrobacter rodentium Intestinal Infection in Mice. Int J Mol Sci. 2021 Aug 31;22(17):9494. [Content Brief]
