173531-57-2
Chemical Structure
Naphthoquine
- CAS No.: 173531-57-2
- Formula:C24H28ClN3O
- Molecular Weight:409.95
InChIKey: VEVMYTDOWUQLGI-UHFFFAOYSA-N
SMILES: ClC1=CC2=NC=CC(NC3=C(CCCC4)C4=C(O)C(CNC(C)(C)C)=C3)=C2C=C1
Biological Activity: Naphthoquine is an orally active antimalarial and antiviral agent. Naphthoquine exhibits ex vivo activity against multidrug-resistant Plasmodium falciparum and Plasmodium vivax, preferentially targeting ring-stage rather than trophozoite-stage parasites. Naphthoquine inhibits coronavirus (SARS-CoV-2, HCoV-OC43, HCoV-229E) replication by affecting viral entry and post-entry replication. Naphthoquine is used for research on malaria and Covid-19[1][2][3].
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Naphthoquine | Naphthoquine is an orally active antimalarial and antiviral agent. Naphthoquine exhibits ex vivo activity against multidrug-resistant Plasmodium falciparum and Plasmodium vivax, preferentially targeting ring-stage rather than trophozoite-stage parasites. Naphthoquine inhibits coronavirus (SARS-CoV-2, HCoV-OC43, HCoV-229E) replication by affecting viral entry and post-entry replication. Naphthoquine is used for research on malaria and Covid-19. | |||||||||||||||||||||
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References
- [1]. Xie Y, et al. The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents. Malaria journal. 2020 Feb 13;19(1):71.
- [2]. Wirjanata G, et al. Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax. Antimicrobial agents and chemotherapy. 2015 Oct;59(10):6117-24.
- [3]. Song Y, et al. Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro. Molecules (Basel, Switzerland). 2022 Jan 21;27(3):712.
