1770840-57-7
Chemical Structure
GS-646089
- CAS No.: 1770840-57-7
- Formula:C12H13N5O4
- Molecular Weight:291.26
InChIKey: BOLRXUJDEAXCSP-QFOLPQNPSA-N
SMILES: NC1=NC=NN2C1=CC=C2[C@H]3[C@H](O)[C@H](O)[C@](CO)(C#N)O3
Biological Activity: GS-646089 is a broad-spectrum antiviral nucleoside analog that exhibits significant inhibitory activity against respiratory syncytial virus (RSV), human metapneumovirus (hMPV), rhinovirus (enterovirus) and enteroviruses. The IC50 of GS-646089 targeting RNA-dependent RNA polymerase (RdRp) ranges from 43 to 46 nM. GS-646089 blocks viral replication by being converted into a triphosphate metabolite intracellularly, which competes with ATP for incorporation into nascent RNA strands and acts as an immediate chain terminator. GS-646089 is the parent compound of the double prodrug GS-7682 (HY-161877), and is used in studies of acute respiratory viral infections and infections caused by related pathogens[1][2][3].
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GS-646089 | GS-646089 is a broad-spectrum antiviral nucleoside analog that exhibits significant inhibitory activity against respiratory syncytial virus (RSV), human metapneumovirus (hMPV), rhinovirus (enterovirus) and enteroviruses. The IC50 of GS-646089 targeting RNA-dependent RNA polymerase (RdRp) ranges from 43 to 46 nM. GS-646089 blocks viral replication by being converted into a triphosphate metabolite intracellularly, which competes with ATP for incorporation into nascent RNA strands and acts as an immediate chain terminator. GS-646089 is the parent compound of the double prodrug GS-7682 (HY-161877), and is used in studies of acute respiratory viral infections and infections caused by related pathogens. | |||||||||||||||||||||
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References
- [1]. Siegel D S, et al. Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4′-CN-4-Aza-7, 9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo-and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys[J]. bioRxiv, 2024: 2024.04. 17.589937.
- [2]. Suresh RR, et al. Prodrug strategies in developing antiviral nucleoside analogs. RSC Med Chem. 2026;17(1):105-131. Published 2026 Jan 2. [Content Brief]
- [3]. Siegel DS, et al. Discovery of GS-7682, a Novel 4'-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys. J Med Chem. 2024;67(15):12945-12968. [Content Brief]
