17771-33-4
17771-33-4
Chemical Structure
7-Hydroxy-2,2-dimethyl-4-chromanone
- CAS No.: 17771-33-4
- Formula:C11H12O3
- Molecular Weight:192.21
IUPAC Name: 7-hydroxy-2,2-dimethylchroman-4-one
InChIKey: PHEWNYMTGPOCOP-UHFFFAOYSA-N
SMILES: O=C1CC(C)(C)OC2=C1C=CC(O)=C2
Biological Activity: 7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC50 of 4.66 mM[1]. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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7-Hydroxy-2,2-dimethyl-4-chromanone | 97.0% | 7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC50 of 4.66 mM. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells. | ||||||||||||||||||||
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References
- [1]. Wang J, et al. Negative regulation of Toll-like receptor signaling pathway. Microbes Infect. 2009 Mar;11(3):321-7. [Content Brief]
- [2]. Aaftaab Sethi, et al. Non-carbohydrate strategies to inhibit lectin proteins with special emphasis on galectins. Eur J Med Chem. 2021 Oct 15:222:113561. [Content Brief]
