1781223-80-0
Chemical Structure
Telisotuzumab
Synonym(s): ABT-700; ABBV-400 Antibody
- CAS No.: 1781223-80-0
- Formula:N/A
- Molecular Weight:(145.5 kDa)
IUPAC Name: spiro[2.3]hexane-5-carbaldehyde
SMILES: [Telisotuzumab]
Biological Activity: Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. The Fc hinge region of Telisotuzumab has been engineered to enhance its rigidity by introducing a new disulfide bond (K222C) and shortening the hinge length (T223del, T225del). Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers[1].
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Telisotuzumab | 99.91% | Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. The Fc hinge region of Telisotuzumab has been engineered to enhance its rigidity by introducing a new disulfide bond (K222C) and shortening the hinge length (T223del, T225del). Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers. | ||||||||||||||||||||
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Telisotuzumab (powder) | Telisotuzumab (ABT-700) (powder) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab (powder) binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab (powder) induces apoptosis. Telisotuzumab (powder) can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers. | |||||||||||||||||||||
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Telisotuzumab (WT IgG1) | 99.54% | Telisotuzumab (WT IgG1) is a monoclonal antibody that retains the natural wild-type IgG1 Fc structure without engineering modification. Telisotuzumab (HY-P99391) is a humanized IgG1 anti-c-Met monoclonal antibody; its Fc hinge region has been engineered to enhance hinge rigidity by introducing a new disulfide bond (K222C) and shortening the hinge length (T223del, T225del). | ||||||||||||||||||||
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