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Telisotuzumab

(Synonyms: ABT-700; ABBV-400 Antibody)
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Based on 1 Customer Validation

Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. The Fc hinge region of Telisotuzumab has been engineered to enhance its rigidity by introducing a new disulfide bond (K222C) and shortening the hinge length (T223del, T225del). Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers.

For research use only. We do not sell to patients.

  • Purity : 99.91%
  • CAS No.: 1781223-80-0
  • Molecular Weight:145.5 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Telisotuzumab
  • Experimental Validation Results for Telisotuzumab
  • Experimental Validation Results for Telisotuzumab
  • Telisotuzumab Chemical Structure
    Telisotuzumab Chemical Structure
CAS No.: 1781223-80-0
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometry analysis of cMet overexpression CHOK1 cells labelling cMet with Telisotuzumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

  • 1/16

    Immobilized HGFR Protein, Human (His) can bind Telisotuzumab. The EC50 for this effect is 65.95 ng/mL.

  • Telisotuzumab Chemical Structure
    1/16
  • Telisotuzumab
  • Flow cytometry analysis of cMet overexpression CHOK1 cells labelling cMet with Telisotuzumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Immobilized HGFR Protein, Human (His) can bind Telisotuzumab. The EC50 for this effect is 65.95 ng/mL.