1801503-93-4
1801503-93-4
Chemical Structure
ODM-207
Synonym(s): BET-IN-4
- CAS No.: 1801503-93-4
- Formula:C22H21N3O3
- Molecular Weight:375.42
IUPAC Name: 6-(3,5-dimethylisoxazol-4-yl)-7-methoxy-3-methyl-1-(pyridin-2-ylmethyl)quinolin-2(1H)-one
InChIKey: YVGWSVHZXWFLIT-UHFFFAOYSA-N
SMILES: O=C1N(CC2=NC=CC=C2)C3=C(C=C(C4=C(C)ON=C4C)C(OC)=C3)C=C1C
Biological Activity: ODM-207 (BET-IN-4) is a potent BET bromodomain protein (BRD4) inhibitor, with an IC50 of ≤ 1 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ODM-207 | 99.58% | ODM-207 (BET-IN-4) is a potent BET bromodomain protein (BRD4) inhibitor, with an IC50 of ≤ 1 μM. | ||||||||||||||||||||
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I-BET151 dihydrochloride | I-BET151 dihydrochloride (GSK1210151A dihydrochloride) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively. | |||||||||||||||||||||
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INCB054329 | 98.02% | INCB054329 is a potent BET inhibitor. | ||||||||||||||||||||
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INCB054329 Racemate | INCB054329 Racemate is a BET protein inhibitor. | |||||||||||||||||||||
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(R)-INCB054329 | 98.94% | (R)-INCB054329 is the isomer of INCB054329 (HY-112504), and can be used as an experimental control. INCB054329 is a potent BET inhibitor. | ||||||||||||||||||||
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CD161 | 99.90% | CD161 is a potent, selective and orally bioavailable bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50s of 28.2 nM and 7.2 nM for BRD4 BD1 and BRD4 BD2, respectively. CD161 has good anticancer activity. | ||||||||||||||||||||
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ZEN-3694 | 99.85% | ZEN-3694 (BET-IN-19) is an orally active BET inhibitor. ZEN-3694 regulates the function of BET proteins, thereby downregulating pathways involved in cell cycle regulation, ER signaling, AR signaling, AR splice variants, MYC, GR, cell growth, inflammation, and cellular immune responses. ZEN-3694 inhibits proliferation, induces apoptosis, reverses the upregulation of CDK6 and CCND1, restores cell cycle arrest, and inhibits CDK6 via miR-34a-5p. ZEN-3694 can be used in research related to HER2 breast cancer and metastatic castration-resistant prostate cancer. | ||||||||||||||||||||
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CD235 | CD235 is a structurally similar analogue of CD161. CD161 is a potent and orally bioavailable BET bromodomain inhibitor. | |||||||||||||||||||||
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I-BET151 | 99.47% | I-BET151 (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively. | ||||||||||||||||||||
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BET-IN-20 | BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage. | |||||||||||||||||||||
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RX-37 | RX-37 is a selective BET inhibitor. RX-37 binds to BET bromodomain proteins (BRD2, BRD3, and BRD4) with Ki values of 3.2-24.7 nM. RX-37 can be used for research of cancers. | |||||||||||||||||||||
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