1822502-44-2
1822502-44-2
Chemical Structure
(S)-3,5-DHPG hydrochloride
- CAS No.: 1822502-44-2
- Formula:C8H10ClNO4
- Molecular Weight:219.62
IUPAC Name: 2-amino-2-(3,5-dihydroxyphenyl)acetic acid hydrochloride
InChIKey: YZUABCCLGVXZIF-UHFFFAOYSA-N
SMILES: O=C(O)C(N)C1=CC(O)=CC(O)=C1.Cl
Biological Activity: (S)-3,5-DHPG hydrochloride is a weak, but selective group I metabotropic glutamate receptors (mGluR) agonist with Ki values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively[1]. (S)-3,5-DHPG hydrochloride exhibits anxiolytic activity in rats subjected to hypoxia[2].
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(S)-3,5-DHPG hydrochloride | (S)-3,5-DHPG hydrochloride is a weak, but selective group I metabotropic glutamate receptors (mGluR) agonist with Ki values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively. (S)-3,5-DHPG hydrochloride exhibits anxiolytic activity in rats subjected to hypoxia. | |||||||||||||||||||||
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References
- [1]. V Mutel, et al. Characterization of [(3)H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections. J Neurochem. 2000 Dec;75(6):2590-601. [Content Brief]
- [2]. Agnieszka Nadlewska, et al. Effect of (S)-3,5-DHPG on Learning, Exploratory Activity and Anxiety in Rats With Experimental Hypoxia. Pol J Pharmacol. Jan-Feb 2002;54(1):11-8. [Content Brief]
